2,2-二甲基-3-氧代丁酸乙酯合成路线 （共 56 条）
反应条件
1: 91 percent / aq. KOH / 5 h
2: oxalyl chloride / diethyl ether / 3 h / 20 °C
3: 1.5 g / Et3N / diethyl ether / 3 h / 0 °C
View Scheme
参考文献
Muthusamy, Sengodagounder; Gunanathan, Chidambaram; Suresh, Eringathodi
Tetrahedron, 2004 , vol. 60, # 36 p. 7885 - 7897
反应条件
1: 82 percent / NaBH4 / ethanol / 48 h / Ambient temperature
2: 47 percent / P2O5 / ethanol / 8 h / Heating
View Scheme
参考文献
Vig,O.P. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1977 , vol. 15B, p. 951 - 952
参考文献
Slawjanow
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1907 , vol. 39, p. 151
Chem. Zentralbl., 1907 , vol. 78, # II p. 134
反应条件
(i) LDA, THF, (ii) CuCl2, DMF; Multistep reaction;
参考文献
Ito,Y. et al.
Journal of the American Chemical Society, 1977 , vol. 99, p. 1487 - 1493
参考文献
Slawjanow
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1907 , vol. 39, p. 151
Chem. Zentralbl., 1907 , vol. 78, # II p. 134
反应条件
1: 83 percent / tetrahydrofuran / 2 h / 25 °C
2: 92 percent / KOH / methanol; H2O / 17 h / Heating
View Scheme
参考文献
Schmidt, Valerie A.; Alexanian, Erik J.
Journal of the American Chemical Society, 2011 , vol. 133, # 30 p. 11402 - 11405
