乙基4-氯噻吩并[2,3-b]吡啶-5-羧酸酯合成路线 （共 7 条）
反应条件
trichlorophosphate
2 h; Heating;
参考文献
Khan,M.A.; Guarconi,A.E.
Heterocycles, 1977 , vol. 6, p. 727 - 729
Full Text Show Details
Khan,M.A.; Guarconi,A.E.
Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 807 - 812
反应条件
1: various solvent(s) / 250 °C
2: POCl3 / 105 °C
View Scheme
参考文献
Bernardino, Alice M. R.; Pinheiro, Luiz C. S.; Ferreira, Vitor Francisco; Azevedo, Alexandre R.; Carneiro, Jose W. De M.; Souza, Thiago M. L.; Frugulhetti, Izabel C. P. P.
Heterocyclic Communications, 2004 , vol. 10, # 6 p. 407 - 410
反应条件
1: pyridine / 40 - 45 °C
2: various solvent(s) / 250 °C
3: POCl3 / 105 °C
View Scheme
参考文献
Bernardino, Alice M. R.; Pinheiro, Luiz C. S.; Ferreira, Vitor Francisco; Azevedo, Alexandre R.; Carneiro, Jose W. De M.; Souza, Thiago M. L.; Frugulhetti, Izabel C. P. P.
Heterocyclic Communications, 2004 , vol. 10, # 6 p. 407 - 410
反应条件
1.1: 480 mg / aq. NaOH / ethanol / 1.5 h / Heating
2.1: thionyl chloride / 2 h / Heating
3.1: 175 mg / aq. ammonia / acetone / 2 h / 0 °C
4.1: 84 mg / cyanuric chloride / dimethylformamide / 0.5 h / 20 °C
5.1: LDA / heptane; tetrahydrofuran; ethylbenzene / 0.58 h / -78 °C
5.2: 1.0 g / iodine / tetrahydrofuran; heptane; ethylbenzene / 4 h / -78 °C
View Scheme
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
sodium hydroxide in ethanol
1.5 h; Heating;
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
1: 480 mg / aq. NaOH / ethanol / 1.5 h / Heating
2: thionyl chloride / 2 h / Heating
3: 175 mg / aq. ammonia / acetone / 2 h / 0 °C
View Scheme
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
1: 480 mg / aq. NaOH / ethanol / 1.5 h / Heating
2: thionyl chloride / 2 h / Heating
3: 175 mg / aq. ammonia / acetone / 2 h / 0 °C
4: 84 mg / cyanuric chloride / dimethylformamide / 0.5 h / 20 °C
View Scheme
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
