1-氧代-2,3-二氢-1H-茚-4-苯甲酸盐合成路线 （共 5 条）
反应条件
1: With thionyl chloride in dichloromethane 4 h; Reflux; 2: With AlCl3, aluminium chloride in dichloromethane T=-50 - 20°C; Reflux;
参考文献
GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; FRORMANN, Sven; LESCH, Bernhard; LEE, Jeewoo; KIM, Yong-Soo; KIM, Myeong-Seop
Patent: WO2010/127855 A1, 2010 ;
Location in patent: Page/Page column 106; 107 ;
反应条件
aluminium trichloride in dichloromethane 3 h; Heating; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 4 p. 515 - 518
反应条件
1: 63 percent / 30percent NaOH / Ambient temperature 2: thionyl chloride, DMF / CH2Cl2 / 4 h / Heating 3: AlCl3 / CH2Cl2 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 4 p. 515 - 518
反应条件
1: 60 percent / benzyltrimethylammonium chloride, NaOH / CH2Cl2 / 4 h / Heating 2: 97 percent / benzyltrimethylammonium chloride, NaOH / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Cannon, Joseph G.; Dushin, Russell G.; Long, John Paul; Ilhan, Mustafa; Jones, Noel D.; Swartzendruber, John K.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 515 - 518
反应条件
1: 60 percent / benzyltrimethylammonium chloride, NaOH / CH2Cl2 / 4 h / Heating
2: 97 percent / benzyltrimethylammonium chloride, NaOH / CH2Cl2 / 2 h / Ambient temperature
3: 95 percent / n-butyl nitrite, HCl / diethyl ether / 1 h / Ambient temperature
4: 72 percent / H2, H2SO4, AcOH / 5percent Pd/C / 2844.3 Torr / Ambient temperature
View Scheme
参考文献
Cannon, Joseph G.; Dushin, Russell G.; Long, John Paul; Ilhan, Mustafa; Jones, Noel D.; Swartzendruber, John K.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 515 - 518
