2,4-二氯-3-硝基吡啶合成路线 （共 29 条）
反应条件
1: 90 percent / SnCl2*2H2O; conc. aq. HCl / diethyl ether / 20 °C 2: 90 percent / N-bromosuccinimide / dimethylformamide / 0.25 h / 0 °C View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1: ethanolic NH3 / 100 °C 2: Na2S; H2O View Scheme
参考文献
Koegl et al.
Recueil des Travaux Chimiques des Pays-Bas, 1948 , vol. 67, p. 29,37
反应条件
sodium acetate in N,N-dimethyl-formamide T=120°C; 3 h;
参考文献
Buckman, Brad Owen; Nicholas, John Beamond; Ramphal, Johnnie Y.; Emayan, Kumaraswamy; Seiwert, Scott D.
Patent: US2014/94456 A1, 2014 ;
Location in patent: Paragraph 0713; 0715 ;
反应条件
1: 90 percent / SnCl2*2H2O; conc. aq. HCl / diethyl ether / 20 °C 2: 90 percent / N-bromosuccinimide / dimethylformamide / 0.25 h / 0 °C 3: 85 percent / K2CO3; Pd(PPh3)2Cl2 / dimethylformamide / 24 h / 100 °C 4: 90 percent / Et3N; Pd(PPh3)2Cl2; CuI / 4 h / 80 °C 5: 48 percent / CuI / dimethylformamide / 18 h / 100 °C View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1: 33 g / triethylamine / dimethylformamide / 2 h / 20 °C 2: 28.6 g / H2; Raney Ni / methanol / 3.5 h / 20 °C 3: 20.1 g / acetic anhydride / 1.5 h / Heating 4: 15.6 g / trifluoroacetic acid / 2 h / 80 °C View Scheme
参考文献
Crey-Desbiolles, Caroline; Kotera, Mitsuharu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1935 - 1941
反应条件
1: With caesium acetate in N,N-dimethyl-formamide 18 h; Inert atmosphereHeating; 2: With water in N,N-dimethyl-formamide T=20°C;
参考文献
Ahn, Sung Oh; Park, Chan Hee; Im, Jun Hwan; Lee, Soon Ok; Lee, Kyoung June; Cho, Seong Wook; Ko, Kwang Seok; Han, Sun Young; Lee, Won Il
Patent: US2011/28467 A1, 2011 ;
Location in patent: Page/Page column 53 ;
US 20110028467 A1
反应条件
1: iron-powder; acetic acid 2: HCl; acetic acid; aqueous H2O2 3: sodium nitrite; copper-powder; aqueous hydrochloric acid / Diazotization View Scheme
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 673,690
反应条件
1: 90 percent / SnCl2*2H2O; conc. aq. HCl / diethyl ether / 20 °C 2: 90 percent / N-bromosuccinimide / dimethylformamide / 0.25 h / 0 °C 3: 85 percent / K2CO3; Pd(PPh3)2Cl2 / dimethylformamide / 24 h / 100 °C View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
hydrogenchloride; tin(ll) chloride in diethyl ether T=20°C; 2 h;
参考文献
Palmer, Andreas Marc; Muench, Gabriela; Brehm, Christof; Zimmermann, Peter Jan; Buhr, Wilm; Feth, Martin Philipp; Simon, Wolfgang Alexander
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 3 p. 1511 - 1530
反应条件
sodium hydrogencarbonate in acetic acid
参考文献
GENENTECH, INC.
Patent: US2011/46066 A1, 2011 ;
