2,4-二氯-3-硝基吡啶合成路线 （共 29 条）
反应条件
in HCl (conc.); diethyl ether; water
参考文献
Amgen Inc.
Patent: US6187777 B1, 2001 ;
反应条件
ammonia in ethanol T=20°C; 96 h;
参考文献
Boehringer Ingelheim Pharma GmbH Co. KG
Patent: US2005/20574 A1, 2005 ;
Location in patent: Page/Page column 16 ;
反应条件
triethylamine in N,N-dimethyl-formamide
T=0 - 20°C; 10 h;
参考文献
Myrexis, Inc.
Patent: US8017780 B1, 2011 ;
Location in patent: Page/Page column 84 ;
反应条件
1: 33 g / triethylamine / dimethylformamide / 2 h / 20 °C
2: 28.6 g / H2; Raney Ni / methanol / 3.5 h / 20 °C
View Scheme
参考文献
Myrexis, Inc.
Patent: US8017780 B1, 2011 ;
反应条件
1: 33 g / triethylamine / dimethylformamide / 2 h / 20 °C
2: 28.6 g / H2; Raney Ni / methanol / 3.5 h / 20 °C
3: 20.1 g / acetic anhydride / 1.5 h / Heating
View Scheme
参考文献
Crey-Desbiolles, Caroline; Kotera, Mitsuharu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1935 - 1941
反应条件
1: iron-powder; acetic acid
2: HCl; acetic acid; aqueous H2O2
View Scheme
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 673,690
反应条件
1-methyl-pyrrolidin-2-one; potassium fluoride; 18-crown-6 ether
T=100°C; Substitution; 2 h;
参考文献
Sledeski; Kubiak; O'Brien; Powers; Powner; Truesdale
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 8114 - 8118
参考文献
Aventis Pharmaceuticals Products Inc.
Patent: US6184382 B2, 2001 ;
参考文献
Aventis Pharmaceuticals Products Inc.
Patent: US6184382 B2, 2001 ;
