反应条件
1.1: 85 percent / NaOMe; MeOH / 24 h / 20 °C
2.1: 99 percent / diisopropylethylamine; methanesulfonyl chloride / CH2Cl2 / 3 h / 0 °C
3.1: NaH / tetrahydrofuran / 0 - 20 °C
3.2: 75 percent / tetrahydrofuran / 19 h / 75 °C
4.1: 74 percent / LiI / dimethylformamide / 17 h / 130 °C
5.1: 59 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Levy, Daniel E.; Bao, Ming; Cherbavaz James, Diana B.; Tomlinson; Sedlock, David M.; Homcy, Charles J.; Scarborough, Robert M.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2177 - 2186
