1-(4-氯苯基)-1-苯基乙醇合成路线 （共 25 条）
反应条件
sodium amide in toluene 4 h; Heating; Yield given;
参考文献
Cahiez, Gerard; Rivas-Enterrios, Jose; Clery, Patrick
Tetrahedron Letters, 1988 , vol. 29, # 30 p. 3659 - 3662
反应条件
sodium amide; toluene
参考文献
Asta-Werke
Patent: DE952715 , 1956 ;
Full Text Show Details
Asta-Werke
Patent: US2785202 , 1953 ;
反应条件
1: bromobenzene With magnesium; iodine in tetrahydrofuran
Inert atmosphereReflux;
2: para-chloroacetophenone in tetrahydrofuran
T=0 - 20°C;
3: With water; ammonium chloride in tetrahydrofuran
T=0°C;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/203763 A1, 2009 ;
Location in patent: Page/Page column 35 ;
US 20090203763 A1
反应条件
sodium ethanolate in ethanol
T=78°C;
参考文献
Clayden, Jonathan; Farnaby, William; Grainger, Damian M.; Hennecke, Ulrich; Mancinelli, Michele; Tetlow, Daniel J.; Hillier, Ian H.; Vincent, Mark A.
Journal of the American Chemical Society, 2009 , vol. 131, # 10 p. 3410 - 3411
反应条件
1: phenyl-magnesium bromide With Et2AlBr in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
2: With titanium(IV) isopropylate; (S)-(minus;)-1,1'-bi-2-naphthol in toluene
T=0°C; 0.5 h; Inert atmosphere;
3: para-chloroacetophenone Further stages;
参考文献
Zhou, Shuangliu; Wu, Kuo-Hui; Chen, Chien-An; Gau, Han-Mou
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3500 - 3505
反应条件
ammonium chloride; [RhCl(η2:η2-cycloocta-1,5-diene)]2 in o-xylene
T=120°C; 25 h;
参考文献
Ueura, Kenji; Miyamura, Sawako; Satoh, Tetsuya; Miura, Masahiro
Journal of Organometallic Chemistry, 2006 , vol. 691, # 12 p. 2821 - 2826
反应条件
in tetrahydrofuran
T=20°C; Grignard reaction; 0.55 h; Inert atmosphere;
参考文献
Riva; Gagliardi; Martinelli; Passarella; Vigo; Rencurosi
Tetrahedron, 2010 , vol. 66, # 17 p. 3242 - 3247
反应条件
1H-imidazole; dihydrogen peroxide; (5,10,15,20-tetrakis(pentafluorophenyl)porphyrin)MnCl in methanol; dichloromethane
T=20°C; 24 h; Further byproducts given;
参考文献
Froehlich; Pietzyk; Smolinka; Goeber
Pharmazie, 1996 , vol. 51, # 6 p. 409 - 414
反应条件
1H-imidazole; dihydrogen peroxide; (5,10,15,20-tetrakis(pentafluorophenyl)porphyrin)MnCl in methanol; dichloromethane
T=20°C; 24 h; Further byproducts given;
参考文献
Froehlich; Pietzyk; Smolinka; Goeber
Pharmazie, 1996 , vol. 51, # 6 p. 409 - 414
反应条件
in diethyl ether
5 h; -20 deg C to r.t.;
参考文献
Dimitrov; Stanchev; Milenkov; Nikiforov; Demirev
Synthesis, 1991 , # 3 p. 228 - 232
