2-硝基-3-氯-苯甲酰胺合成路线 （共 4 条）
反应条件
potassium hydroxide; bromine 1.) water, 30 min, 0 deg C, 2.) water, 70-75 deg C, 45 min; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4455 - 4463
反应条件
thionyl chloride in DMF (N,N-dimethyl-formamide) T=20 - 120°C; 2.5 h;
参考文献
Shimojo, Masato; Taniguchi, Kana
Patent: US2003/236260 A1, 2003 ;
Location in patent: Page 116 ;
US 20030236260 A1
反应条件
1: With thionyl chloride
T=80°C; 1 h;
2: With ammonia in dichloromethane; water
T=0°C; 0.416667 h;
参考文献
Shimojo, Masato; Taniguchi, Kana
Patent: US2003/236260 A1, 2003 ;
Location in patent: Page 116 ;
US 20030236260 A1
反应条件
ammonium hydroxide
0.333333 h;
参考文献
Guengoer, Timur; Fouquet, Andre; Teulon, Jean-Marie; Provost, Daniel; Cazes, Michele; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4455 - 4463
