2,5-二氯-3-甲基吡啶合成路线 （共 8 条）
反应条件
hydrogenchloride; trichlorophosphate in N,N-dimethyl-formamide T=125°C; 0.75 h;
参考文献
Shvekhgeimer, M.-G. A.; Kobrakov, K. I.; Sychev, S. S.; Promonenkov, V. K.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 4 p. 428 - 433
Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 4 p. 514 - 519
反应条件
copper(l) chloride in acetonitrile T=150°C; 2 h;
参考文献
Martin, Pierre; Steiner, Eginhard; Streith, Jacques; Winkler, Tammo; Bellus, Daniel
Tetrahedron, 1985 , vol. 41, # 19 p. 4057 - 4078
反应条件
trichlorophosphate T=190°C; 4 h;
参考文献
Shvekhgeimer, M.-G. A.; Kobrakov, K. I.; Sychev, S. S.; Promonenkov, V. K.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 4 p. 428 - 433
Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 4 p. 514 - 519
反应条件
hydrogenchloride T=175 - 180°C;
参考文献
Martin, Pierre; Steiner, Eginhard; Streith, Jacques; Winkler, Tammo; Bellus, Daniel
Tetrahedron, 1985 , vol. 41, # 19 p. 4057 - 4078
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite T=50°C; 0.166667 h;
参考文献
Ciurla; Puszko
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 10 p. 1173 - 1177
反应条件
1: 68.55 percent / hydrazine hydrate / Raney nickel / ethanol / 70 deg C, 10 min; room temperature, 0.5 h 2: 45 percent / aq. NaNO2, CuCl, HCl / 0.17 h / 50 °C View Scheme
参考文献
Chemistry of Heterocyclic Compounds, , vol. 32, # 10 p. 1173 - 1177
反应条件
1: 82 percent / Et3N / diethyl ether / 1 h / Ambient temperature 2: 77 percent / POCl3 / 4 h / 190 °C View Scheme
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 25, # 4 p. 428 - 433
Khimiya Geterotsiklicheskikh Soedinenii, , # 4 p. 514 - 519
反应条件
Cu2Cl2; triphenylphosphine; trichlorophosphate T=180 - 190°C; 3 h; Yield given;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 25, # 4 p. 428 - 433
Khimiya Geterotsiklicheskikh Soedinenii, , # 4 p. 514 - 519
