2-氯-5-碘-3-甲基吡啶合成路线 （共 8 条）
反应条件
Ki; sodium thiosulfate in ethylene glycol dimethyl ether; acetonitrile; pentane
参考文献
Abbott Laboratories
Patent: US5733912 A1, 1998 ;
反应条件
chlorine; sodium nitrite in water
反应条件
1: 2-Chloro-5-iodo-3-methylpyridine With n-butyllithium in tetrahydrofuran; diethyl ether T=-78°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; diethyl ether T=-78 - 20°C; 1 h; 3: With water
参考文献
Journal of Medicinal Chemistry, , vol. 57, # 6 p. 2536 - 2548
反应条件
1: 82 percent / dimethylformamide / 6.5 h / 160 °C 2: diisobutyl aluminum hydride / toluene / 4 h / cooling View Scheme
参考文献
Synthetic Communications, , vol. 36, # 9 p. 1235 - 1245
反应条件
in N,N-dimethyl-formamide T=160°C; 6.5 h;
参考文献
Kagabu, Shinzo
Synthetic Communications, 2006 , vol. 36, # 9 p. 1235 - 1245
反应条件
1: 82 percent / dimethylformamide / 6.5 h / 160 °C 2: diisobutyl aluminum hydride / toluene / 4 h / cooling 3: 89 percent / thionyl chloride / CHCl3 / 1 h / Heating View Scheme
参考文献
Kagabu, Shinzo
Synthetic Communications, 2006 , vol. 36, # 9 p. 1235 - 1245
反应条件
1: 2-Chloro-5-iodo-3-methylpyridine With n-butyllithium in tetrahydrofuran; diethyl ether
T=-78°C; 1 h;
2: carbon dioxide in tetrahydrofuran; diethyl ether
T=-78 - 20°C; 1 h;
3: With water; sodium hydroxide
参考文献
Fontaine, Fanny; Hequet, Arnaud; Voisin-Chiret, Anne-Sophie; Bouillon, Alexandre; Lesnard, Aurelien; Cresteil, Thierry; Jolivalt, Claude; Rault, Sylvain
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2536 - 2548
反应条件
1: 82 percent / dimethylformamide / 6.5 h / 160 °C
2: diisobutyl aluminum hydride / toluene / 4 h / cooling
View Scheme
参考文献
Kagabu, Shinzo
Synthetic Communications, 2006 , vol. 36, # 9 p. 1235 - 1245
