1: 4-fluoro-1H-pyrrolo[2,3-b]pyridine With AlCl3, aluminium chloride in dichloromethane
T=20°C; 0.5 h;
2: 2-bromo acetyl bromide in dichloromethane
T=50°C; 1 h;
3: With water in dichloromethane
T=100°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/103050 A2, 2005 ;
Location in patent: Page/Page column 179 ;
WO 2005/103050 A2