2,4,6-三甲基苯硼酸合成路线 （共 68 条）
反应条件
1: With diisobutylaluminium hydride; magnesium; lithium chloride in tetrahydrofuran; toluene T=20°C; 15 h; Inert atmosphere; 2: With boric acid trimethyl ester in tetrahydrofuran; toluene T=0°C; Inert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran; toluene T=0°C; Inert atmosphere;
参考文献
Leermann, Timo; Leroux, Frederic R.; Colobert, Francoise
Organic Letters, 2011 , vol. 13, # 17 p. 4479 - 4481
反应条件
hydrolysis with dild. HCl;;
参考文献
Gmelin Handbook: B: B-Verb.13, 4.7.2.7, page 226 - 237
反应条件
mesitylmagnesium bromide in diethyl ether mesitylmagnesium bromide (from Mg and mesityl bromide in ether) and B(OMe3)3 added to stirred ether (-78°C), allowed to warm to room temp., stirred (17 h); addn. of water, extn. (ether), dried (MgSO4), evapn. (vac.), recrystn. (CHCl3-light petroleum (40-60°C) 1:1); elem. anal.;
参考文献
Brown, Paul; Mahon, Mary F.; Molloy, Kieran C.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1992 , # 24 p. 3503 - 3510
反应条件
magnesium in N,N-dimethyl-formamide byproducts: Mg(2+); Electrolysis; electrolysis carried out in a single-compartment cell at room temp., starting materials dissolved in DMF containing KBr or n-Bu4NBr, solvent andexcess B(OCH3)3 evaporated under vacuum, medium hydrolysed at 0° C with an HCl or H2SO4 soln.; extraction with Et2O (3 x 20 ml if the solvent evaporated or 3 x 60 ml otherwise), organic phase dried over sodium or magnesium sulfate and concentrated under vacuum, side product phenol formation avoided by work-up under inert atmosphere;
参考文献
Laza, Carine; Dunach, Elisabet; Serein-Spirau, Francoise; Moreau, Joel J. E.; Vellutini, Luc
New Journal of Chemistry, 2002 , vol. 26, # 4 p. 373 - 375
反应条件
in tetrahydrofuran addn. of B-compd. to org. compd. in THF, stirring (-78°C, 1.5 h); addn. of satd. soln. of aq. NH4Cl (-78°C), warming (room temp.),DDN: OF H2O, shaking with ether, washing of ether extracts (satd. aq. NaHCO3 and satd. brine), drying (Na2SO4), filtration, evapn. (vac.), crystn. (H2O);
参考文献
Morgan, Jacqueline; Pinhey, John T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 715 - 720
反应条件
diethyl ether T=-78°C; und anschliessend mit wss.HCl;
参考文献
Journal of Organic Chemistry, , vol. 23, p. 1579
参考文献
Angewandte Chemie, , vol. 96, p. 444 - 445
反应条件
1: With boric acid trimethyl ester T=20°C; Electrochemical reactionMg consumable anode, supporting electrolyte; 2: T=0°C; Acid hydrolysis; Further stages.;
参考文献
Laza, Carine; Dunach, Elisabet; Serein-Spirau, Francoise; Moreau, Joel J. E.; Vellutini, Luc
New Journal of Chemistry, 2002 , vol. 26, # 4 p. 373 - 375
反应条件
Pd(2-[2-(benzylthio)phenyliminomethyl]-4-bromophenol-(H))Cl; potassium carbonate in N,N-dimethyl-formamide T=90°C; 5 h; Sealed tubeInert atmosphere;
参考文献
Gogoi, Prasanta; Kalita, Mukul; Barman, Pranjit
Synlett, 2014 , vol. 25, # 6 art. no. 47, p. 866 - 870
反应条件
trimethylsilylazide; tetrabutyl ammonium fluoride; copper(l) chloride in tetrahydrofuran; methanol 5 h; RefluxIn air;
参考文献
Li, Yu; Gao, Lian-Xun; Han, Fu-She
Chemistry - A European Journal, 2010 , vol. 16, # 27 p. 7969 - 7972
