2-(4-氰基苯基)苯乙酮合成路线 （共 44 条）
反应条件
sodium t-butanolate; palladium diacetate; 2'-hydroxy-2-di-cyclohexylphosphinobiphenyl-4'-sulfonic acid in N,N-dimethyl-formamide
T=80°C; 14.75 h;
参考文献
Meudt, Andreas; Nerdinger, Sven; Lehnemann, Bernd Wilhelm; Vogel, Till; Snieckus, Victor
Patent: US2008/221350 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); Tedicyp in N,N-dimethyl-formamide
T=130°C; Heck reaction; 20 h;
参考文献
Battace, Ahmed; Feuerstein, Marie; Lemhadri, Mhamed; Zair, Touriya; Doucet, Henri; Santelli, Maurice
European Journal of Organic Chemistry, 2007 , # 19 p. 3122 - 3132
反应条件
hydrogenchloride in toluene
T=150°C; 0.0833333 h; microwave irradiation;
参考文献
Nilsson; Larhed; Hallberg
Journal of the American Chemical Society, 2001 , vol. 123, # 34 p. 8217 - 8225
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate in tetrahydrofuran
T=75°C; 2.5 h; Inert atmosphere;
参考文献
Wang, Heng-Yen; Mueller, Daniel S.; Sachwani, Rachna M.; Kapadia, Rachel; Londino, Hannah N.; Anderson, Laura L.
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3203 - 3221
反应条件
palladium diacetate; 1,4-di(diphenylphosphino)-butane; zinc in 1,4-dioxane
T=100°C; Negishi coupling reaction; P=7500.75 Torr; 16 h; Inert atmosphereAutoclave;
参考文献
Wu, Xiao-Feng; Schranck, Johannes; Neumann, Helfried; Beller, Matthias
Chemistry - An Asian Journal, 2012 , vol. 7, # 1 p. 40 - 44
反应条件
1: 92 percent / Pd(OAc)2; 1,3-bis(diphenylphosphino)propane; TlOAc / dimethylformamide; H2O / 5 h / 80 °C
2: Pd(OAc)2; Et3N / dimethylformamide / 5 h / 100 °C
3: conc. aq. HCl / toluene / 0.08 h / 150 °C / microwave irradiation
View Scheme
参考文献
Nilsson; Larhed; Hallberg
Journal of the American Chemical Society, 2001 , vol. 123, # 34 p. 8217 - 8225
反应条件
1: Pd(OAc)2; DPPP; Et3N / dimethylformamide / 18 h / 60 °C
2: Pd(OAc)2; Et3N / dimethylformamide / 5 h / 100 °C
3: conc. aq. HCl / toluene / 0.08 h / 150 °C / microwave irradiation
View Scheme
参考文献
Nilsson; Larhed; Hallberg
Journal of the American Chemical Society, 2001 , vol. 123, # 34 p. 8217 - 8225
反应条件
1: Pd(OAc)2; Et3N / dimethylformamide / 5 h / 100 °C
2: conc. aq. HCl / toluene / 0.08 h / 150 °C / microwave irradiation
View Scheme
参考文献
Nilsson; Larhed; Hallberg
Journal of the American Chemical Society, 2001 , vol. 123, # 34 p. 8217 - 8225
反应条件
potassium hydroxide in methanol
0.0833333 h; Ambient temperature;
参考文献
Anders, Ernst; Gassner, Thomas
Chemische Berichte, 1984 , vol. 117, # 3 p. 1034 - 1038
反应条件
ZnF2; tri-tert-butyl phosphine; cesium fluoride; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl-formamide
T=70°C; Product distribution; Further Variations:Reagents;
参考文献
Su, Weiping; Raders, Steven; Verkade, John G.; Liao, Xuebin; Hartwig, John F.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 35 p. 5852 - 5855
