2-(4-氰基苯基)苯乙酮合成路线 （共 44 条）
反应条件
in N,N-dimethyl-formamide; toluene
参考文献
Sterling Drug Inc.
Patent: US4898880 A1, 1990 ;
反应条件
palladium diacetate; 1,4-di(diphenylphosphino)-butane; zinc in 1,4-dioxane
T=100°C; Negishi coupling reaction; 3 h; Inert atmosphere;
参考文献
Wu, Xiao-Feng; Schranck, Johannes; Neumann, Helfried; Beller, Matthias
Chemistry - An Asian Journal, 2012 , vol. 7, # 1 p. 40 - 44
反应条件
1: ZnCl2
2: 1) (Me3Si)2NNa / 1) THF, -60 deg C, 15 min, 2) THF, -60 deg C to r.t.
3: 81 percent / 5 percent KOH / methanol / 0.08 h / Ambient temperature
View Scheme
参考文献
Anders, Ernst; Gassner, Thomas
Chemische Berichte, 1984 , vol. 117, # 3 p. 1034 - 1038
反应条件
1: ZnCl2
2: 1) (Me3Si)2NNa / 1) THF, -60 deg C, 15 min, 2) THF, -60 deg C to r.t.
3: 81 percent / 5 percent KOH / methanol / 0.08 h / Ambient temperature
View Scheme
参考文献
Anders, Ernst; Gassner, Thomas
Chemische Berichte, 1984 , vol. 117, # 3 p. 1034 - 1038
反应条件
water; palladium diacetate; potassium hydrogencarbonate; tri-cyclo-hexyl-phosphine
T=100°C; Suzuki coupling; P=7500.75 Torr; 20 h; Inert atmosphere;
参考文献
Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 5 p. 788 - 792
反应条件
phosphorus trichoride
Erwaermen des Reaktionsprodukts mit Benzol und Aluminiumchlorid;
参考文献
Khan; Linnell
Journal of Pharmacy and Pharmacology, 1949 , vol. 1, p. 230,233
反应条件
1: 1) (Me3Si)2NNa / 1) THF, -60 deg C, 15 min, 2) THF, -60 deg C to r.t.
2: 81 percent / 5 percent KOH / methanol / 0.08 h / Ambient temperature
View Scheme
参考文献
Anders, Ernst; Gassner, Thomas
Chemische Berichte, 1984 , vol. 117, # 3 p. 1034 - 1038
反应条件
aluminium trichloride in carbon disulfide
参考文献
Wagner; Voigt
Pharmazie, 1976 , vol. 31, # 7 p. 432 - 436
反应条件
cadmium
1.) glyme, 0 deg C, 5 h, 2.) benzene, RT, 20 h; Yield given. Multistep reaction;
参考文献
Burkhardt, Elizabeth R.; Rieke, Reuben D.
Journal of Organic Chemistry, 1985 , vol. 50, # 3 p. 416 - 417
反应条件
hydrogenchloride; cobaloxime(I)
Yield given. Multistep reaction;
参考文献
Tada; Inoue; Okabe
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 5 p. 1420 - 1423
