1,2,3,4-四氢-6-异喹啉溴酸盐合成路线 （共 17 条）
反应条件
water; hydrogen bromide 5 h; Reflux;
参考文献
Yang, Su Hui; Song, Chin-Hee; Van, Hue Thi My; Park, Eunsook; Khadka, Daulat Bikram; Gong, Eun-Yeung; Lee, Keesook; Cho, Won-Jea
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3414 - 3418
反应条件
hydrogen bromide T=120°C; 3 h;
参考文献
Sall; Grunewald
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2208 - 2216
反应条件
hydrogen bromide T=105°C; 5 h;
参考文献
Dalence-Guzman, Maria F.; Berglund, Magnus; Skogvall, Staffan; Sterner, Olov
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2499 - 2512
反应条件
in 2-(3-methoxy-phenyl)-ethylamine
参考文献
US2010/113512 A1, ;
US 20100113512 A1
反应条件
1: 91 percent / Et3N / tetrahydrofuran / 24 h / Ambient temperature 2: 51 percent / polyphosphoric acid / 0.17 h / 145 °C 3: 98 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 4: 90 percent / 48percent aq. HBr / 3 h / 120 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 12 p. 2208 - 2216
反应条件
1: 98 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 2: 90 percent / 48percent aq. HBr / 3 h / 120 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 12 p. 2208 - 2216
反应条件
1: 51 percent / polyphosphoric acid / 0.17 h / 145 °C 2: 98 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 3: 90 percent / 48percent aq. HBr / 3 h / 120 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 12 p. 2208 - 2216
反应条件
1: ammonium acetate; acetic acid / 12 h / 100 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 80 °C 3: hydrogenchloride / water / 1 h / 60 °C 4: hydrogenchloride / isopropyl alcohol; water / 18 h / 20 °C 5: hydrogen bromide; water / 5 h / |Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 8 p. 3414 - 3418
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 80 °C 2: hydrogenchloride / water / 1 h / 60 °C 3: hydrogenchloride / isopropyl alcohol; water / 18 h / 20 °C 4: hydrogen bromide; water / 5 h / |Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 8 p. 3414 - 3418
反应条件
1: hydrogenchloride / isopropyl alcohol; water / 18 h / 20 °C 2: hydrogen bromide; water / 5 h / |Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 8 p. 3414 - 3418
