3,6-二氢-4-甲基-2-(2-甲基丙基)-2H-吡喃合成路线 （共 15 条）
反应条件
dimethylaluminum chloride in n-heptane; dichloromethane
T=25°C;
参考文献
Snider, Barry B.; Rodini, David J.
Tetrahedron Letters, 1980 , vol. 21, p. 1815 - 1818
反应条件
zinc in ethanol
T=70 - 80°C; further dehalogenation agent; Title compound not separated from byproducts;
参考文献
Kazaryan, P. I.; Avakyan, O. V.; Avakyan, S. V.; Gevorkyan, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 9 p. 988 - 992
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 9 p. 1189 - 1193
反应条件
cation-exchange resin KU-2 in toluene
T=110°C; 2.5 h;
参考文献
Romanov, N. A.; Kantor, E. A.; Musavirov, R. S.; Karakhanov, R. A.; Rakhmankulov, D. L.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, p. 1576 - 1581
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 8 p. 1762 - 1767
反应条件
perchloric acid in tetrahydrofuran
20 h; Ambient temperature;
参考文献
Kitahara, Takeshi; Takagi, Yoshikazu; Matsui, Masanao
Agricultural and Biological Chemistry, 1980 , vol. 44, # 4 p. 897 - 902
反应条件
sulfuric acid
T=110°C; 2.5 h;
参考文献
Romanov, N. A.; Kantor, E.A.; Brudnik, I. M.; Musavirov, R. S.; Kiladze, T. K.; Rakhmankulov, D. L.
J. Appl. Chem. USSR (Engl. Transl.), 1982 , vol. 55, # 12 p. 2778 - 2780,2526 - 2528
反应条件
sulfuric acid
T=25°C;
参考文献
Margot, Christian; Rizzolio, Michele; Schlosser, Manfred
Tetrahedron, 1990 , vol. 46, # 7 p. 2411 - 2424
反应条件
1: SO3 / CH2Cl2 / -40 °C
2: 2.) KBH4 / 1.) CH2Cl2, -70 deg C, 10 min
View Scheme
参考文献
Gavrishova, T.I.; Shastin, A.V.; Balenkova, E.S.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 4.1 p. 580 - 583
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 4 p. 673 - 677
反应条件
1: 99 percent / LiAlH4 / diethyl ether / 1 h
2: 72 percent / 60percent HClO4 / tetrahydrofuran / 20 h / Ambient temperature
View Scheme
参考文献
Kitahara, Takeshi; Takagi, Yoshikazu; Matsui, Masanao
Agricultural and Biological Chemistry, 1980 , vol. 44, # 4 p. 897 - 902
反应条件
1: 62 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C
2: 99 percent / LiAlH4 / diethyl ether / 1 h
3: 72 percent / 60percent HClO4 / tetrahydrofuran / 20 h / Ambient temperature
View Scheme
参考文献
Kitahara, Takeshi; Takagi, Yoshikazu; Matsui, Masanao
Agricultural and Biological Chemistry, 1980 , vol. 44, # 4 p. 897 - 902
反应条件
1: 60 percent / KBr / benzene; aq. HBr / 2 h / 0 °C
2: 81 percent / CHCl3; HCl / 5 h / 0 °C
3: 75 percent / Zn / ethanol / 70 - 80 °C / further dehalogenation agent
View Scheme
参考文献
Kazaryan, P. I.; Avakyan, O. V.; Avakyan, S. V.; Gevorkyan, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 9 p. 988 - 992
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 9 p. 1189 - 1193
