4-(5-庚基嘧啶-2-基)苯甲腈合成路线 （共 2 条）
反应条件
1: 1.) Mg / 1.) ether, 30 min, reflux, 2.) ether, 1 h, reflux
2: H2N-NH2*H2O, KOH / bis-(2-hydroxy-ethyl) ether / 1.) 135 deg C, 2 h, 2.) 195 deg C, 4 h
View Scheme
参考文献
Osman, Maged A.; Huynh-Ba, T.
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1983 , vol. 38, # 10 p. 1221 - 1226
反应条件
1: With sulfuric acid; water; acetic acid
T=120°C; 8 h;
2: With sodium hydroxide in water
3: With hydrogenchloride; water
参考文献
Lund, Birgitte W.; Knapp, Anne Eeg; Piu, Fabrice; Gauthier, Natalie K.; Begtrup, Mikael; Hacksell, Uli; Olsson, Roger
Journal of Medicinal Chemistry, 2009 , vol. 52, # 6 p. 1540 - 1545
