N1-(2,3-二氢-1H-茚-5-基)乙酰胺合成路线 （共 30 条）
反应条件
1: (i) CrO3, aq. AcOH, Ac2O, (ii) aq. HCl 2: (i) aq. HCl, NaNO2, (ii) /BRN= 3587244/ 3: aq. H2O2, KOH 4: aq. HCl / Heating View Scheme
参考文献
Allinger,N.L.; Jones,E.S.
Journal of Organic Chemistry, 1962 , vol. 27, p. 70 - 76
反应条件
1: chromium(VI) oxide / acetic acid; water / 1 h / 55 °C 2: N-bromosuccinmide; silica gel / 144 h / 20 °C / |Darkness View Scheme
参考文献
Yilmaz, Makbule; Tutar, Ahmet; Erenler, Ramazan
Journal of Chemical Research, 2013 , vol. 37, # 4 p. 232 - 235
反应条件
(i) CrO3, aq. AcOH, Ac2O, (ii) aq. HCl; Multistep reaction;
参考文献
Sczepan; Rettig; Tolmachev; Kurdyukov
Physical Chemistry Chemical Physics, 2001 , vol. 3, # 17 p. 3555 - 3561
反应条件
1: (i) CrO3, aq. AcOH, Ac2O, (ii) aq. HCl 2: (i) aq. HCl, NaNO2, (ii) aq. H2SO4 View Scheme
参考文献
Allinger,N.L.; Jones,E.S.
Journal of Organic Chemistry, 1962 , vol. 27, p. 70 - 76
反应条件
1: 15 percent / KNO3, H2SO4 / Ambient temperature 2: 97 percent / 2 N aq. HCl / 9 h / 85 °C View Scheme
参考文献
Schroder; Lehmann; Rufer; Bottcher
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 1 p. 35 - 42
反应条件
1: acetic anhydride; chromium(VI) oxide / water; acetic acid / 10 °C 2: sodium methylate / methanol; ethylene glycol dimethyl ether / 20 °C / |Cooling with ice View Scheme
参考文献
MERCK SHARP and DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng
Patent: WO2013/39802 A1, 2013 ;
反应条件
chromium(VI) oxide in water; acetic acid T=55°C; 1 h;
参考文献
Yilmaz, Makbule; Tutar, Ahmet; Erenler, Ramazan
Journal of Chemical Research, 2013 , vol. 37, # 4 p. 232 - 235
反应条件
1: 86 percent / bromine; acetic acid / 1 h / 10 °C 2: 61 percent / aq. CrO3; acetic acid / 1.5 h / 16 - 18 °C View Scheme
参考文献
Scheigetz; Zamboni; Roy
Synthetic Communications, 1995 , vol. 25, # 18 p. 2791 - 2806
反应条件
1: 80 percent / Br2, HOAc / 0.25 h / 10 °C 2: 80 percent / CrO3, HOAc / 0.25 h / 50 - 55 °C 3: 100 percent / 6 M aq. HCl / 1 h / Heating View Scheme
参考文献
Scheigetz; Zamboni; Roy
Synthetic Communications, 1995 , vol. 25, # 18 p. 2791 - 2806
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0°C; 0.0833333 h; 2: N-(2,3-dihydro-1H-inden-5-yl)acetamide T=20 - 80°C; 5.1667 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1908752 A1, 2008 ;
Location in patent: Page/Page column 24 ;
