N1-(2,3-二氢-1H-茚-5-基)乙酰胺合成路线 （共 30 条）
反应条件
1: (i) CrO3, aq. AcOH, Ac2O, (ii) aq. HCl 2: (i) aq. HCl, NaNO2, (ii) /BRN= 3587244/ View Scheme
参考文献
Allinger,N.L.; Jones,E.S.
Journal of Organic Chemistry, 1962 , vol. 27, p. 70 - 76
参考文献
Hach
Chemicke Listy, 1953 , vol. 47, p. 1486,1489,1490
Chem.Abstr., 1955 , p. 979
反应条件
in 1,4-dioxane
T=0 - 20°C; 48 h;
参考文献
Hay, Michael P.; Hicks, Kevin O.; Pchalek, Karin; Lee, Ho H.; Blaser, Adrian; Pruijn, Frederik B.; Anderson, Robert F.; Shinde, Sujata S.; Wilson, William R.; Denny, William A.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 21 p. 6853 - 6865
反应条件
acetic anhydride; acetic acid
T=50°C; 4 h;
参考文献
Hodogaya Chemical Co., Ltd.
Patent: EP1752441 A1, 2007 ;
Location in patent: Page/Page column 15 ;
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 0.5 h;
参考文献
MERCK SHARP and DOHME CORP.; TANG, Haifeng; PIO, Barbara; TEUMELSAN, Nardos; PASTERNAK, Alexander; DEJESUS, Reynalda
Patent: WO2013/62892 A1, 2013 ;
Location in patent: Page/Page column 44; 45 ;
反应条件
pyridine; acetic anhydride in ethyl acetate
参考文献
Zeneca Limited; British Technology Group Ltd.
Patent: US5789417 A1, 1998 ;
反应条件
in pyridine; hydrogenchloride
参考文献
Boehringer Biochemia Robin, S.p.A.
Patent: US4692447 A1, 1987 ;
反应条件
in tert-butyl methyl ether
T=20°C; 4 h; Molecular sieve;
参考文献
Lal, Samridhi; Snape, Timothy J.
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 83, p. 80 - 86
反应条件
hydrogenchloride; acetic anhydride in acetic acid
Beckman rearrangement; 4 h;
参考文献
Sczepan; Rettig; Tolmachev; Kurdyukov
Physical Chemistry Chemical Physics, 2001 , vol. 3, # 17 p. 3555 - 3561
参考文献
Hoffmann-La Roche Inc.
Patent: US4435406 A1, 1984 ;
