2,3,5-三-O-乙酰基-6-氯嘌呤-9-β-D-呋喃核糖苷合成路线 （共 37 条）
反应条件
1: Et3N / CHCl3 / Heating
2: NH3 / ethanol / 24 h / Ambient temperature
View Scheme
参考文献
Nair, Vasu; Fasbender, Allen J.
Tetrahedron, 1993 , vol. 49, # 11 p. 2169 - 2184
反应条件
1: dimethylaminopyridine, pyridine / Ambient temperature
2: methanolic ammonia / 16 h / Ambient temperature
View Scheme
参考文献
Agathocleous, Demetrios C.; Bulman Page, Philip C.; Cosstick, Richard; Galpin, Ian J.; McLennan, Alexander G.; Prescott, Mark
Tetrahedron, 1990 , vol. 46, # 6 p. 2047 - 2058
反应条件
1.1: zinc dibromide / tetrahydrofuran / 1 h / -78 - 20 °C
1.2: 5 h / 55 °C
2.1: methanol; ammonia / 2 h / 20 °C
View Scheme
参考文献
Hassan, Abdalla E.A.; Abou-Elkhair, Reham A.I.; Riordan, James M.; Allan, Paula W.; Parker, William B.; Khare, Rashmi; Waud, William R.; Montgomery, John A.; Secrist III, John A.
European Journal of Medicinal Chemistry, 2012 , vol. 47, # 1 p. 167 - 174
反应条件
1: 87 percent / triethylamine / methanol / 0.5 h / Ambient temperature
2: 97 percent / ammonia / methanol / Ambient temperature
3: 84 percent / toluene-4-sulphonic acid monohydrate / tetrahydrofuran / 1 h / 50 °C
4: 88 percent / 3-chloroperbenzoic acid / CH2Cl2 / 2.5 h / -5 °C
5: 70 percent / N,N-di-isopropylethylamine / N,N-dimethyl-acetamide / 28 h / 70 - 75 °C
6: 0.65 g / aq. formic acid / 3 h / Ambient temperature
7: hydrogen / palladium on carbon / ethanol; acetic acid; H2O / 2 h
View Scheme
参考文献
Buck, Ildiko M.; Reese, Colin B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 11 p. 2937 - 2942
反应条件
1: dimethylaminopyridine, pyridine / Ambient temperature
2: methanolic ammonia / 16 h / Ambient temperature
View Scheme
参考文献
Agathocleous, Demetrios C.; Bulman Page, Philip C.; Cosstick, Richard; Galpin, Ian J.; McLennan, Alexander G.; Prescott, Mark
Tetrahedron, 1990 , vol. 46, # 6 p. 2047 - 2058
反应条件
1.1: diisopropylethylamine / ethanol / 18 h / Heating
1.2: 58 percent / NH3 / methanol / 0 - 20 °C
2.1: 100 percent / H2; acetic acid / Pd/C / methanol; H2O / 3 h
View Scheme
参考文献
Middleton, Richard J.; Briddon, Stephen J.; Cordeaux, Yolande; Yates, Andrew S.; Dale, Clare L.; George, Michael W.; Baker, Julian G.; Hill, Stephen J.; Kellam, Barrie
Journal of Medicinal Chemistry, 2007 , vol. 50, # 4 p. 782 - 793
反应条件
1: ethanol / 1 h / 100 °C / Microwave irradiation
2: potassium carbonate / ethanol / 0.17 h / 100 °C / Microwave irradiation
View Scheme
参考文献
Niu, Hong-Ying; Xia, Chao; Qu, Gui-Rong; Wu, Shan; Jiang, Yi; Jin, Xin; Guo, Hai-Ming
Chemistry - An Asian Journal, 2012 , vol. 7, # 1 p. 45 - 49
