2',3',5'-三-O-乙酰-6-氯-2-碘嘌呤核苷合成路线 （共 15 条）
反应条件
1: 93 percent / NH3 / ethanol / 23 h / 25 °C 2: 55 percent / H2O / 7.5 h / Irradiation View Scheme
参考文献
Nair; Young
Journal of Organic Chemistry, 1985 , vol. 50, # 3 p. 406 - 408
反应条件
1: With sulfuric acid in water 3 h; Reflux; 2: With sodium hydroxide in water pH=4.5;
参考文献
Montanaro, Gabriele; Bertinaria, Massimo; Rolando, Barbara; Fruttero, Roberta; Lucas, Christopher D.; Dorward, David A.; Rossi, Adriano G.; Megson, Ian L.; Gasco, Alberto
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 2107 - 2116
反应条件
1: 95 percent / CuI, (PPh3)2PdCl2, Et3N / dioxane / 2 h / Ambient temperature
2: 90 percent / conc. NH4OH / dioxane / 20 h / 70 °C
View Scheme
参考文献
Matsuda; Shinozaki; Yamaguchi; Homma; Nomoto; Miyasaka; Watanabe; Abiru
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 241 - 252
反应条件
1: 93 percent / NH3 / ethanol / 23 h / 25 °C
2: 84 percent / pyridine / 1.) 0 deg C, 1 h, 2.) 25 deg C, 2 h
3: 51 percent / n-pentyl nitrite, diiodomethane / 7 h / 80 °C
View Scheme
参考文献
Nair; Young
Journal of Organic Chemistry, 1985 , vol. 50, # 3 p. 406 - 408
反应条件
1.1: sulfuric acid / water / 3 h / |Reflux
1.2: pH 4.5
2.1: N-ethyl-N,N-diisopropylamine / ethanol / |Reflux; |Inert atmosphere
3.1: potassium carbonate / dimethyl sulfoxide / 50 °C
View Scheme
参考文献
Montanaro, Gabriele; Bertinaria, Massimo; Rolando, Barbara; Fruttero, Roberta; Lucas, Christopher D.; Dorward, David A.; Rossi, Adriano G.; Megson, Ian L.; Gasco, Alberto
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 2107 - 2116
