2,3-二甲基-４-氯吡啶过氧化物合成路线 （共 20 条）
反应条件
hydrogenchloride; sodium chloride; (benzyl)-tri-(butyl)-ammonium chloride in water; acetonitrile 12 h; Heating / reflux;
参考文献
US2004/63957 A1, ;
Page 4 ;
反应条件
1: in ethanol T=65°C; Large scale reaction; 2: With sodium hydroxide in ethanol; water; toluene pH=7.5 - 8.5; Large scale reaction;
参考文献
Organic Process Research and Development, , vol. 14, # 3 p. 562 - 567
反应条件
1: 53 percent / conc. H2SO4, 65percent HNO3 / 20 h / 95 °C 2: 53 percent / conc. HCl / 12 h / 170 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
in water; dimethyl sulfoxide T=40 - 50°C;
参考文献
Arigen, Pharmaceuticals, Inc.
Patent: EP2103608 A1, 2009 ;
Location in patent: Page/Page column 10 ;
反应条件
1: methanol With sodium hydroxide in dimethyl sulfoxide T=60°C; 1 h; 2: 4-chloro-2,3-dimethylpyridine 1-oxide in dimethyl sulfoxide T=60°C; 4 h;
参考文献
Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar
Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818
反应条件
1: 5 h / 120 °C 2: NaOH / H2O / 1 h / 25 °C View Scheme
参考文献
SATO PHARMACEUTICAL CO., LTD.
Patent: US2002/173517 A1, 2002 ;
反应条件
1.1: NaOH / dimethylsulfoxide / 1 h / 60 °C 1.2: 15 g / dimethylsulfoxide / 4 h / 60 °C 2.1: 5 h / 120 °C 3.1: NaOH / H2O / 1 h / 25 °C View Scheme
参考文献
Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar
Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818
反应条件
1.1: NaOH / dimethylsulfoxide / 1 h / 60 °C 1.2: 15 g / dimethylsulfoxide / 4 h / 60 °C 2.1: 5 h / 120 °C 3.1: NaOH / H2O / 1 h / 25 °C 4.1: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C 5.1: 88 percent / NaOH / H2O / 3 h / 25 °C View Scheme
参考文献
Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar
Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818
反应条件
1.1: NaOH / dimethylsulfoxide / 1 h / 60 °C 1.2: 15 g / dimethylsulfoxide / 4 h / 60 °C 2.1: 5 h / 120 °C View Scheme
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
反应条件
1.1: NaOH / dimethylsulfoxide / 1 h / 60 °C 1.2: 15 g / dimethylsulfoxide / 4 h / 60 °C 2.1: 5 h / 120 °C 3.1: NaOH / H2O / 1 h / 25 °C 4.1: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C 5.1: 88 percent / NaOH / H2O / 3 h / 25 °C 6.1: 57 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / -15 - -10 °C View Scheme
参考文献
Pharmazie, , vol. 60, # 11 p. 814 - 818
