(3,4-二甲氧基苯甲酰基氨基)-乙酸合成路线 （共 3 条）
反应条件
trifluoroacetic acid in dichloromethane
T=0 - 20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KOWALSKI, Jennifer A.; MARSHALL, Daniel Richard; PROKOPOWICZ, Anthony S. III; SCHLYER, Sabine; SIBLEY, Robert; SORCEK, Ronald John; WU, Di; WU, Frank; YOUNG, Erick Richard Roush
Patent: WO2010/126811 A1, 2010 ;
Location in patent: Page/Page column 151-152 ;
WO 2010/126811 A1
反应条件
1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 25 °C
2: potassium hydroxide; water / ethanol / 2 h / 70 °C
View Scheme
参考文献
ALIOS BIOPHARMA, INC.; WANG, Guangyi; BEIGELMAN, Leonid; TRUONG, Anh; NAPOLITANO, Carmela; ANDREOTTI, Daniele; HE, Haiying
Patent: WO2014/31784 A1, 2014 ;
参考文献
Redel; Bouteville
Bulletin de la Societe Chimique de France, 1949 , p. 443,446
