5-氯-1-甲基-1H-吲哚-2-羧酸乙酯合成路线 （共 5 条）
参考文献
Synthelabo
Patent: US6075021 A1, 2000 ;
反应条件
1: ethyl 5-chloro-1H-indole-2-carboxylate With sodium hydride in N,N-dimethyl-formamide
0.166667 h;
2: methyl iodide in N,N-dimethyl-formamide
22 h;
参考文献
Kim, Ronald M.; Bittner, Amy R.; Sinz, Christopher Joseph; Parmee, Emma R.
Patent: US2007/88071 A1, 2007 ;
Location in patent: Page/Page column 27 ;
US 20070088071 A1
反应条件
1: 1.) NaNO2, HCl, 2.) KOH
2: H3PO4
3: NaH / dimethylsulfoxide
View Scheme
参考文献
Fagan, Gay P.; Chapleo, Christopher B.; Lane, Anthony C.; Myers, Malcolm; Roach, Alan G.; et al
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 944 - 948
反应条件
1: H3PO4
2: NaH / dimethylsulfoxide
View Scheme
参考文献
Fagan, Gay P.; Chapleo, Christopher B.; Lane, Anthony C.; Myers, Malcolm; Roach, Alan G.; et al
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 944 - 948
反应条件
sodium hydroxide; tetrabutylammomium bromide in diethyl ether
6 h; Ambient temperature;
参考文献
Lehr, Matthias
Journal of Medicinal Chemistry, 1997 , vol. 40, # 17 p. 2694 - 2705
