4-(1,2,4-噁二唑-3-基)苯胺合成路线 （共 4 条）
反应条件
water; ammonium chloride; zinc in tetrahydrofuran
T=20 - 65°C;
参考文献
Forest Laboratories Holdings Limited
Patent: US2009/239810 A1, 2009 ;
Location in patent: Page/Page column 54 ;
US 20090239810 A1
反应条件
1: 2.2 g / BF3*Et2O / Heating
2: 79 percent / H2, conc. HCl / 10percent Pd/C / aq. ethanol / 2585.7 Torr
View Scheme
参考文献
Haugwitz, R. D.; Martinez, A. J.; Venslavsky, J.; Angel, R. G.; Maurer, B. V.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1234 - 1241
反应条件
1: potassium carbonate; hydroxylamine hydrochloride / ethanol / Reflux
2: Reflux
3: hydrogen / palladium 10 on activated carbon / methanol / 20 °C / 760.05 Torr
View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; POPOVICI-MULLER, Janeta; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.; TRAVINS, Jeremey; YAN, Shunqi
Patent: WO2012/9678 A1, 2012 ;
WO 2012/009678 A1
反应条件
1: Reflux
2: hydrogen / palladium 10 on activated carbon / methanol / 20 °C / 760.05 Torr
View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; POPOVICI-MULLER, Janeta; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.; TRAVINS, Jeremey; YAN, Shunqi
Patent: WO2012/9678 A1, 2012 ;
WO 2012/009678 A1
