4-甲氧基-3-甲基-苯甲酰氯合成路线 （共 9 条）
反应条件
1: diethyl ether / 0 °C 2: aq. Ag2O / dioxane View Scheme
参考文献
Young, Jonathan R.; Huang, Song X.; Chen, Irene; Walsh, Thomas F.; DeVita, Robert J.; Wyvratt Jr., Matthew J.; Goulet, Mark T.; Ren, Ning; Lo, Jane; Yang, Yi Tien; Yudkovitz, Joel B.; Cheng, Kang; Smith, Roy G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1723 - 1727
反应条件
1: 2.) SOCl2 / 2.) Et2O 2: 90 percent / s-BuLi / 1.) Et2O, 0 deg C, 2.) Et2O 3: 2.) H3O(1+) / 1.) THF View Scheme
参考文献
Baker, Raymond; O'Mahony, Mary J.; Swain, Christopher J.
Journal of the Chemical Society, Chemical Communications, 1985 , # 19 p. 1326 - 1328
参考文献
Smith, Amos B.; Schow, Steven R.; Bloom, Jonathan D.; Thompson, Andrew S.; Winzenberg, Kevin N.
Journal of the American Chemical Society, 1982 , vol. 104, # 14 p. 4015 - 4018
反应条件
1: Ag2O / ethanol / 20 °C
2: SOCl2 / Heating
View Scheme
参考文献
Van Muijlwijk-Koezen; Timmerman; Vollinga; Frijtag von Drabbe Kuenzel; De Groote; Visser; IJzerman
Journal of Medicinal Chemistry, 2001 , vol. 44, # 5 p. 749 - 762
反应条件
1: CH2Cl2 / 2 h / 25 °C
2: SOCl2 / CH2Cl2 / 0.5 h / 25 °C
View Scheme
参考文献
Schow,S.R.; Bloom,J.D.; Thompson,A.S.
Journal of the American Chemical Society, 1986 , vol. 108, p. 2662
反应条件
thionyl chloride
1.) CH2Cl2; Yield given. Multistep reaction;
参考文献
Smith, Amos B.; Schow, Steven R.; Bloom, Jonathan D.; Thompson, Andrew S.; Winzenberg, Kevin N.
Journal of the American Chemical Society, 1982 , vol. 104, # 14 p. 4015 - 4018
反应条件
1: CH2Cl2 / 2 h / 25 °C
2: SOCl2 / CH2Cl2 / 0.5 h / 25 °C
3: 1.) sec-butyllithium / 1.) ether, 0 deg C, 4 h; 2.) ether, -78 deg C, 15 min then to r.t.
View Scheme
参考文献
Smith, Amos B.; Schow, Steven R.; Bloom, Jonathan D.; Thompson, Andrew S.; Winzenberg, Kevin N.
Journal of the American Chemical Society, 1982 , vol. 104, # 14 p. 4015 - 4018
反应条件
1: CH2Cl2 / 2 h / 25 °C
2: SOCl2 / CH2Cl2 / 0.5 h / 25 °C
3: 1.) sec-butyllithium / 1.) ether, 0 deg C, 4 h; 2.) ether, -78 deg C, 15 min then to r.t.
4: 98 percent / diethyl ether / 0.25 h / 0 °C
5: 88 percent / 3M H2SO4 / tetrahydrofuran / 12 h / 25 °C
View Scheme
参考文献
Schow,S.R.; Bloom,J.D.; Thompson,A.S.
Journal of the American Chemical Society, 1986 , vol. 108, p. 2662
反应条件
1: diethyl ether / 0 °C
2: aq. Ag2O / dioxane
3: (COCl)2; DMF / CH2Cl2
View Scheme
参考文献
Young, Jonathan R.; Huang, Song X.; Chen, Irene; Walsh, Thomas F.; DeVita, Robert J.; Wyvratt Jr., Matthew J.; Goulet, Mark T.; Ren, Ning; Lo, Jane; Yang, Yi Tien; Yudkovitz, Joel B.; Cheng, Kang; Smith, Roy G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1723 - 1727
