反应条件
1: 68.2 g / di-isobutylaluminium hydride / hexane / 0.5 h / -60 °C 2: 1.) butyl-lithium / 1.) THF, hexane, 30 min, -60 deg C; 2.) THF, RT, 1 h 3: 1.) borane*THF, cyclohexane; 2.) aq. KOH, H2O2 / 1.) THF, 2 h; 2.) MeOH, RT, 1.5 h 4: 82 percent / diethyl ether / Ambient temperature 5: 56 percent / lithium di-isopropylamide, HMPA / tetrahydrofuran 6: 88 percent / KOH / methanol / 16 h / Ambient temperature 7: 20 percent / Et3N, diphenylphosphoryl azide / toluene / 7 h / Heating 8: Heating 9: 1.) O3; 2.) NaBH4 / 1.) CH2Cl2, -15 deg C, 8 min; 2.) EtOH, 0 deg C, 1.5 h View Scheme
参考文献
Miles, Nicholas J.; Sammes, Peter G.; Kennewell, Peter D.; Westwood, Robert
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2299 - 2306
