2-苯基噻唑-4-甲酸乙酯合成路线 （共 22 条）
反应条件
oxygen; copper diacetate in N,N-dimethyl-formamide T=120°C; P=760.051 Torr; 12 h; Molecular sieve;
参考文献
Wang, Yiyun; Li, Ziyuan; Huang, Yue; Tang, Changhua; Wu, Xiaoming; Xu, Jinyi; Yao, Hequan
Tetrahedron, 2011 , vol. 67, # 38 p. 7406 - 7411
反应条件
in ethanol T=20°C; 2 h; Reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
Location in patent: Paragraph 00226 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in toluene T=80°C; Suzuki coupling; 4 h;
参考文献
Hodgetts, Kevin J.; Kershaw, Mark T.
Organic Letters, 2002 , vol. 4, # 8 p. 1363 - 1365
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 1 h; Molecular sieve;
参考文献
Huang, Yue; Gan, Haifeng; Li, Shang; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan
Tetrahedron Letters, 2010 , vol. 51, # 13 p. 1751 - 1753
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 2 h; Molecular sieve;
参考文献
Huang, Yue; Gan, Haifeng; Li, Shang; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan
Tetrahedron Letters, 2010 , vol. 51, # 13 p. 1751 - 1753
反应条件
Lawesson's reagent in 1,4-dioxane 12 h; Reflux;
参考文献
Tetrahedron Letters, , vol. 55, # 16 p. 2671 - 2674
参考文献
Bayer Aktiengesellschaft
Patent: US5811429 A1, 1998 ;
US 5811429 A
反应条件
N-bromosuccinmide; meta-chloroperoxybenzoic acid in tetrachloromethane 6 h; Heating;
参考文献
Badr, Mahmoud Zarif Amin; Aly, Morsy Mohamed; Fahmy, Atiat Mohamed; Mansour, Mansour Esmael Younis
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 6 p. 1844 - 1847
反应条件
boron trifluoride diethyl etherate in ethylene glycol dimethyl ether 3 h; Heating;
参考文献
Kim, Hong-Seok; Kwon, Il-Cheon; Kim, Oh-Hwoan
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 937 - 940
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 24 h;
参考文献
Huang, Yue; Gan, Haifeng; Li, Shang; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan
Tetrahedron Letters, 2010 , vol. 51, # 13 p. 1751 - 1753
