2-苯基噻唑-4-甲酸乙酯合成路线 （共 22 条）
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 20 p. 3491 - 3495
反应条件
1: 80.1 percent / 2 h / 80 - 90 °C 2: 72.9 percent / NBS, benzoyl peroxide / CCl4 / 6 h / Heating View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 54, # 6 p. 1844 - 1847
反应条件
1: 80.1 percent / 2 h / 80 - 90 °C 2: 72.9 percent / NBS, benzoyl peroxide / CCl4 / 6 h / Heating View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 54, # 6 p. 1844 - 1847
反应条件
1: sodium hydride; 18-crown-6 ether / toluene / 20 - 60 °C / |Cooling with ice 2: Lawesson's reagent / 1,4-dioxane / 12 h / |Reflux View Scheme
参考文献
Tetrahedron Letters, , vol. 55, # 16 p. 2671 - 2674
反应条件
1: aq. KOH / 50 °C 2: oxalyl chloride; DMF / CH2Cl2 / 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
反应条件
1: sodium hydroxide; water / methanol / 1.03 h / 20 °C 2: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 4 h / 22 °C 3: triethylamine / dichloromethane / 1 h / 20 °C / |Cooling with ice 4: tetrahydrofuran; anhydrous butyl ether / 0.53 h / 0 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
反应条件
water; sodium hydroxide in methanol T=20°C; 1.03 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
Location in patent: Paragraph 00217 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78°C; 2 h;
参考文献
Kwon, Il-Chun; Koh, Young Kook; Choi, Jun-Hyeak; Kim, Hong-Seok
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1883 - 1886
反应条件
1.1: hydrazine hydrate / ethanol / 2 h / 20 °C 2.1: sodium hydrogencarbonate; water / 1,4-dioxane / 0.08 h / 20 °C 2.2: 20 °C View Scheme
参考文献
Thore; Gupta, Sunil V.; Baheti, Kamalkishor G.
Medicinal Chemistry Research, 2013 , vol. 22, # 8 p. 3802 - 3811
反应条件
1: NH3 / methanol
2: POCl3 / pyridine
3: NH3, H2S / methanol
4: ethanol
5: NaOH / methanol; H2O
6: (i) Et3N, ClCO2Et, THF, (ii) NaN3, H2O, (iii) /BRN= 385737/, AcOH
7: aq. HCl
8: methanol; diethyl ether
View Scheme
参考文献
Hall; Walker
Journal of the Chemical Society. Perkin transactions 1, 1966 , vol. 16, p. 1357 - 1360
