1-乙氧基-3-三氟甲基-1,3-丁二烯合成路线 （共 52 条）
反应条件
1: in 1,4-dioxane T=20°C; 2: With ammonium acetate in 1,4-dioxane 18 h; Heating / reflux;
参考文献
VALEANT PHARMACEUTICALS INTERNATIONAL, INC.
Patent: WO2009/18466 A1, 2009 ;
Location in patent: Page/Page column 13; 14 ;
WO 2009/018466 A1
反应条件
chloro-trimethyl-silane; zinc in tetrahydrofuran T=40°C; Inert atmosphereReflux;
参考文献
INTERMUNE, INC.
Patent: US2009/318455 A1, 2009 ;
Location in patent: Page/Page column 82-83 ;
反应条件
1: chloro-trimethyl-silane With zinc in tetrahydrofuran 0.5 h; Inert atmosphere; 2: ETFBO; chloroacetonitrile in tetrahydrofuran T=20 - 40°C; 2 h; Inert atmosphere; 3: With hydrogenchloride in tetrahydrofuran; water 1 h; RefluxInert atmosphere;
参考文献
Jiang, Biao; Xiong, Wennan; Zhang, Xiaobing; Zhang, Fangjiang
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 531 - 534
反应条件
in ethanol T=70°C; Cycloaddition; 24 h;
参考文献
Synthetic Communications, , vol. 30, # 4 p. 677 - 687
反应条件
triethylamine T=20°C; Cooling with ice;
参考文献
SOLVAY SA; BRAUN, Max
Patent: WO2010/37688 A1, 2010 ;
Location in patent: Page/Page column 9 ;
反应条件
ammonium acetate; acetic acid T=20°C; Heating / reflux;
参考文献
PEAKDALE MOLECULAR LIMITED
Patent: WO2006/59103 A2, 2006 ;
Location in patent: Page/Page column 31-32 ;
反应条件
ammonium acetate; acetic acid 1.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2006/59103 A2, ;
Page/Page column 29 ;
反应条件
acetic acid 1 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2006/59103 A2, ;
Page/Page column 30 ;
反应条件
in ethanol T=70°C; Cycloaddition; 24 h;
参考文献
Chu, Qianli; Wang, Yanli; Zhu, Shizheng
Synthetic Communications, 2000 , vol. 30, # 4 p. 677 - 687
反应条件
sulfuric acid in methanol T=60°C; 24 h; Overall yield = 50 percent; regioselective reaction;
参考文献
Bonacorso, Helio G.; Correa, Michele S.; Porte, Liliane M.F.; Pittaluga, Everton P.; Zanatta, Nilo; Martins, Marcos A.P.
Tetrahedron Letters, 2012 , vol. 53, # 41 p. 5488 - 5491
