1-乙氧基-3-三氟甲基-1,3-丁二烯合成路线 （共 52 条）
反应条件
in ethanol; water; ethyl acetate
参考文献
Idenix Pharmaceuticals, Inc.
Patent: US2010/260710 A1, 2010 ;
反应条件
in dichloromethane T=20°C; 2 h;
参考文献
Vdovenko, Sergey I.; Gerus, Igor I.; Kukhar, Valery P.
Journal of Physical Organic Chemistry, 2007 , vol. 20, # 3 p. 190 - 200
反应条件
hydrogenchloride; piperidinium acetate in methanol; water
参考文献
Simoneau, Bruno
Patent: US2002/28807 A1, 2002 ;
反应条件
ammonia in acetonitrile T=20°C; 14 h;
参考文献
Wu, Gang; Mikkilineni, Amarendra B.; Sher, Philip M.; Murugesan, Natesan; Gu, Zhengxiang
Patent: US2006/287341 A1, 2006 ;
Location in patent: Page/Page column 42 ;
US 20060287341 A1
反应条件
hydroxylamine hydrochloride; sodium carbonate in water
T=20°C; 2 h;
参考文献
Gerus, I. I.; Gorbunova, M. G.; Vdovenko, S. I.; Yagupol'skii, Yu. L.; Kukhar', V. P.
Journal of Organic Chemistry USSR (English Translation), 1990 , vol. 26, # 9.1 p. 1623 - 1628
Zhurnal Organicheskoi Khimii, 1990 , vol. 26, # 9 p. 1877 - 1883
反应条件
toluene-4-sulfonic acid in toluene
2 h; Heating;
参考文献
Kondratov, Ivan S.; Gerus, Igor I.; Kacharov, Aleksey D.; Gorbunova, Marina G.; Kukhar, Valery P.; Froehlich, Roland
Journal of Fluorine Chemistry, 2005 , vol. 126, # 3 p. 355 - 362
反应条件
sulfuric acid in water
T=50°C; 16 h;
参考文献
Martins, Marcos A. P.; Marzari, Mara R. B.; Frizzo, Clarissa P.; Zanatta, Marcileia; Buriol, Lilian; Andrade, Valquiria P.; Zanatta, Nilo; Bonacorso, Helio G.
European Journal of Organic Chemistry, 2012 , # 36 p. 7112 - 7119
反应条件
magnesium in diethyl ether
T=0°C; 2 h; further times; Product distribution;
参考文献
Gorbunova, M. G.; Gerus, I. I.; Kukhar, V. P.
Journal of Fluorine Chemistry, 1993 , vol. 65, # 1-2 p. 25 - 28
反应条件
magnesium in diethyl ether
T=0°C; 2 h; further times; Product distribution;
参考文献
Gorbunova, M. G.; Gerus, I. I.; Kukhar, V. P.
Journal of Fluorine Chemistry, 1993 , vol. 65, # 1-2 p. 25 - 28
反应条件
1: in ethanol
2 h; Heating;
2: With hydrogenchloride in dichloromethane
T=1°C; 25 h; Further stages.;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
