2-异丙基吡唑并[1,5-a]吡啶合成路线 （共 6 条）
反应条件
bromine in chloroform
参考文献
Kyorin Pharmaceutical Co., Ltd.
Patent: US4578392 A1, 1986 ;
反应条件
1: With sulfuric acid
3 h; Heating / reflux;
2: With sodium hydroxide in water
T=0°C; pH=> 10; Product distribution / selectivity;
参考文献
AVIGEN, INC.
Patent: WO2007/146087 A2, 2007 ;
Location in patent: Page/Page column 80 ;
反应条件
potassium hydroxide; sulfuric acid; acetic anhydride
参考文献
Kyorin Pharmaceutical Co., Ltd.
Patent: US4028370 A1, 1977 ;
反应条件
1: acetyl chloride With AlCl3, aluminium chloride in dichloromethane
T=20°C; 0.666667 h;
2: 2-isopropyl-pyrazolo[1,5-a]pyridine in dichloromethane
T=20°C; 20 h; Product distribution / selectivity;
参考文献
AVIGEN, INC.
Patent: WO2007/146087 A2, 2007 ;
Location in patent: Page/Page column 75 ;
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
T=20°C; 0.166667 h;
2: 2-isopropyl-pyrazolo[1,5-a]pyridine T=20°C; 19 h;
3: With sodium hydroxide in water
pH=8;
参考文献
AVIGEN, INC.
Patent: WO2007/146087 A2, 2007 ;
Location in patent: Page/Page column 73 ;
反应条件
trichlorophosphate in N-methyl-acetamide
参考文献
Kyorin Pharmaceutical Co., Ltd.
Patent: US4028370 A1, 1977 ;
