吡唑并[1,5-a]吡啶-2(1H)-酮合成路线 （共 5 条）
反应条件
1: With potassium hydroxide; hydroxylamine-o-sulphonic acid in water T=20°C; 0.5 h; 2: With sodium carbonate in water pH=9; 3: With acetic acid in water pH=5;
参考文献
SCHWARZ PHARMA AG
Patent: EP1972628 A1, 2008 ;
Location in patent: Page/Page column 31 ;
EP 1972628 A1
反应条件
hydroxylamine-o-sulphonic acid in water 40 h;
参考文献
WO2013/43521 A1, ;
Page/Page column 54 ;
反应条件
acetic acid in water
反应条件
trichlorophosphate T=145°C; 6 h;
参考文献
MERCK SHARP and DOHME CORP.; BENNETT, D. Jonathan; CAI, Jaiqiang; CARSWELL, Emma; COOKE, Andrew; HOYT, Scott, B.; LONDON, Clare; MACLEAN, John; PARK, Min, K.; RATCLIFFE, Paul; XIONG, Yusheng; SAMANTA, Swapan Kumar; KULKARNI, Bheemashankar, A.
Patent: WO2013/43521 A1, 2013 ;
Location in patent: Page/Page column 54; 55 ;
反应条件
sodium; dimethyl sulfate in methanol
参考文献
Kyorin Pharmaceutical Co., Ltd.
Patent: US4028370 A1, 1977 ;
