1-(5-氨基-2-氯嘧啶-4-基)-1-丁酮合成路线 （共 4 条）
反应条件
1: 89 percent / NH3(gas) / ethanol / 48 h / 100 °C 2: 81 percent / 6 h / 100 °C 3: SOCl2, DMF / 0.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 12 p. 1820 - 1826
反应条件
1: 89 percent / NH3(gas) / ethanol / 48 h / 100 °C 2: 81 percent / 6 h / 100 °C View Scheme
参考文献
Rewcastle, Gordon W.; Bridges, Alexander J.; Fry, David W.; Rubin, J. Ronald; Denny, William A.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1820 - 1826
反应条件
hydrogen; magnesium oxide; 5-palladium/activated carbon in 1,4-dioxane
T=20°C; P=2812.78 Torr; 5 h;
参考文献
SYNGENTA LIMITED; SYNGENTA PARTICIPATIONS AG
Patent: WO2004/56826 A1, 2004 ;
Location in patent: Page 74 ;
反应条件
hydrogen; triethylamine; 5-palladium/activated carbon in methanol
P=2625.26 Torr; 3 h;
参考文献
SYNGENTA LIMITED; SYNGENTA PARTICIPATIONS AG
Patent: WO2004/56826 A1, 2004 ;
Location in patent: Page 74-75 ;
