5-溴-2-叔丁基嘧啶-4-羧酸合成路线 （共 5 条）
反应条件
1: 2,2-dimethylpropaneimidamide hydrochloride With sodium ethanolate in ethanol
T=50°C;
2: 2,3-dibromomalealdehydic acid in ethanol
T=55°C;
3: With hydrogenchloride; sodium ethanolate
more than 3 stages;
参考文献
Carter, Percy H.; Cherney, Robert J.; Batt, Douglas G.; Duncia, John V.; Gardner, Daniel S.; Ko, Soo S.; Srivastava, Anurag S.; Yang, Michael G.
Patent: US2005/54627 A1, 2005 ;
Location in patent: Page/Page column 38 ;
US 20050054627 A1
反应条件
1: 2,2-dimethylpropaneimidamide hydrochloride With sodium ethanolate in ethanol
2: 2,3-dibromomalealdehydic acid in ethanol
T=50 - 55°C;
3: With hydrogenchloride; sodium ethanolate
more than 3 stages;
参考文献
Carter, Percy H.; Cherney, Robert J.; Batt, Douglas G.; Brown, Gregory D.; Duncia, John V.; Gardner, Daniel S.; Yang, Michael G.
Patent: US2005/54626 A1, 2005 ;
Location in patent: Page/Page column 35 ;
US 20050054626 A1
反应条件
sodium ethanolate; sodium in ethanol
参考文献
Imperial Chemical Industries PLC
Patent: US4661488 A1, 1987 ;
反应条件
in methanol; hexane; benzene
48 h;
参考文献
Carter, Percy H.; Cherney, Robert J.; Batt, Douglas G.; Brown, Gregory D.; Duncia, John V.; Gardner, Daniel S.; Yang, Michael G.
Patent: US2005/54626 A1, 2005 ;
Location in patent: Page/Page column 39 ;
US 20050054626 A1
