1.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / Inert atmosphere 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h 4.1: Dess-Martin periodane / dichloromethane / 2 h 5.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water / 2 h 5.2: pH 2 6.1: BOP-Cl; triethylamine / acetonitrile / Inert atmosphere 7.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 20 °C 7.2: pH 3 8.1: dichloromethane / 2 h / 20 °C 9.1: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme

1.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water / 2 h 1.2: pH 2 2.1: BOP-Cl; triethylamine / acetonitrile / Inert atmosphere 3.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 20 °C 3.2: pH 3 4.1: dichloromethane / 2 h / 20 °C 5.1: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme

1.1: benzotriazol-1-ol; triethylamine / dichloromethane / 0.03 h 2.1: dichloromethane / 1 h 3.1: benzotriazol-1-ol; triethylamine / dichloromethane / 0.03 h 4.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere 5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / 20 °C / Inert atmosphere 6.1: methanol / 3 h 7.1: BOP-Cl; triethylamine / acetonitrile / Inert atmosphere 8.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 20 °C 8.2: pH 3 9.1: dichloromethane / 2 h / 20 °C 10.1: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme

1.1: Lawesson's reagent / toluene / 2 h / Reflux 2.1: ethanol / 2 h / Reflux 3.1: selenium(IV) oxide / acetic acid / 12 h / Reflux 4.1: tetrahydrofuran / 0.5 h / 20 °C 5.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C 6.1: ammonium acetate / 12 h / Reflux 7.1: potassium carbonate / ethanol; dichloromethane 8.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C 9.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h 10.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 3 h / Inert atmosphere 11.1: BOP-Cl; triethylamine / acetonitrile / 3 h 12.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere 13.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / Inert atmosphere 14.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h 15.1: Dess-Martin periodane / dichloromethane / 2 h 16.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water / 2 h 16.2: pH 2 17.1: BOP-Cl; triethylamine / acetonitrile / Inert atmosphere 18.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 20 °C 18.2: pH 3 19.1: dichloromethane / 2 h / 20 °C 20.1: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme

1.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C 2.1: ammonium acetate / 12 h / Reflux 3.1: potassium carbonate / ethanol; dichloromethane 4.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C 5.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h 6.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 3 h / Inert atmosphere 7.1: BOP-Cl; triethylamine / acetonitrile / 3 h 8.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere 9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / Inert atmosphere 10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h 11.1: Dess-Martin periodane / dichloromethane / 2 h 12.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water / 2 h 12.2: pH 2 13.1: BOP-Cl; triethylamine / acetonitrile / Inert atmosphere 14.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 20 °C 14.2: pH 3 15.1: dichloromethane / 2 h / 20 °C 16.1: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme

1.1: ammonium acetate / 12 h / Reflux 2.1: potassium carbonate / ethanol; dichloromethane 3.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C 4.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h 5.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 3 h / Inert atmosphere 6.1: BOP-Cl; triethylamine / acetonitrile / 3 h 7.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere 8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / Inert atmosphere 9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h 10.1: Dess-Martin periodane / dichloromethane / 2 h 11.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water / 2 h 11.2: pH 2 12.1: BOP-Cl; triethylamine / acetonitrile / Inert atmosphere 13.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 20 °C 13.2: pH 3 14.1: dichloromethane / 2 h / 20 °C 15.1: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme

1.1: potassium carbonate / ethanol; dichloromethane 2.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C 3.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h 4.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 3 h / Inert atmosphere 5.1: BOP-Cl; triethylamine / acetonitrile / 3 h 6.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere 7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / Inert atmosphere 8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h 9.1: Dess-Martin periodane / dichloromethane / 2 h 10.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water / 2 h 10.2: pH 2 11.1: BOP-Cl; triethylamine / acetonitrile / Inert atmosphere 12.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 20 °C 12.2: pH 3 13.1: dichloromethane / 2 h / 20 °C 14.1: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme

1.1: selenium(IV) oxide / acetic acid / 12 h / Reflux 2.1: tetrahydrofuran / 0.5 h / 20 °C 3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C 4.1: ammonium acetate / 12 h / Reflux 5.1: potassium carbonate / ethanol; dichloromethane 6.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C 7.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h 8.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 3 h / Inert atmosphere 9.1: BOP-Cl; triethylamine / acetonitrile / 3 h 10.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere 11.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / Inert atmosphere 12.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h 13.1: Dess-Martin periodane / dichloromethane / 2 h 14.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water / 2 h 14.2: pH 2 15.1: BOP-Cl; triethylamine / acetonitrile / Inert atmosphere 16.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 20 °C 16.2: pH 3 17.1: dichloromethane / 2 h / 20 °C 18.1: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme

1.1: ammonium hydroxide / water / 2 h / 70 °C 2.1: Lawesson's reagent / toluene / 2 h / Reflux 3.1: ethanol / 2 h / Reflux 4.1: selenium(IV) oxide / acetic acid / 12 h / Reflux 5.1: tetrahydrofuran / 0.5 h / 20 °C 6.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C 7.1: ammonium acetate / 12 h / Reflux 8.1: potassium carbonate / ethanol; dichloromethane 9.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C 10.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h 11.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 3 h / Inert atmosphere 12.1: BOP-Cl; triethylamine / acetonitrile / 3 h 13.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere 14.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / Inert atmosphere 15.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h 16.1: Dess-Martin periodane / dichloromethane / 2 h 17.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water / 2 h 17.2: pH 2 18.1: BOP-Cl; triethylamine / acetonitrile / Inert atmosphere 19.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 20 °C 19.2: pH 3 20.1: dichloromethane / 2 h / 20 °C 21.1: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme

1.1: dichloromethane / 1 h / Inert atmosphere 2.1: benzotriazol-1-ol; triethylamine / dichloromethane / 0.03 h 3.1: dichloromethane / 1 h 4.1: benzotriazol-1-ol; triethylamine / dichloromethane / 0.03 h 5.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere 6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / 20 °C / Inert atmosphere 7.1: methanol / 3 h 8.1: BOP-Cl; triethylamine / acetonitrile / Inert atmosphere 9.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 20 °C 9.2: pH 3 10.1: dichloromethane / 2 h / 20 °C 11.1: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme