(S)-(-)-1-氨基-2-(甲氧甲基)吡咯烷合成路线 (共 8 条)
反应条件
1: 1) lithium diisopropylamide / 1) ether, 0 deg C, 4 h, 2) -78 deg C, 2 h; 10 h, -78 deg C to RT 2: O3 / pentane / -78 °C 3: LiAlH4 / tetrahydrofuran View Scheme
参考文献
Angewandte Chemie, , vol. 99, # 4 p. 359 - 360
反应条件
1: O3 / CH2Cl2 / -78 °C 2: LAH / recycling of the chiral auxiliary View Scheme
参考文献
Tetrahedron Letters, , vol. 27, # 30 p. 3491 - 3494
反应条件
1: O3 / pentane / -78 °C 2: LiAlH4 / tetrahydrofuran View Scheme
参考文献
Angewandte Chemie, , vol. 99, # 4 p. 359 - 360
反应条件
potassium hydroxide; KOCl
参考文献
Journal of Organic Chemistry, , vol. 73, # 24 p. 9647 - 9656
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Angewandte Chemie, , vol. 99, # 4 p. 359 - 360
反应条件
Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 40, # 8 p. 1345 - 1359
反应条件
n-butyllithium in diethyl ether 2 h; Ambient temperature;
参考文献
Enders; Bettray; Raabe; Runsink
Synthesis, 1994 , # SPEC. ISS. p. 1322 - 1326
参考文献
Enders, Dieter; Syrig, Ralf; Raabe, Gerhard; Fernandez, Rosario; Gasch, Consolacion; Lassaletta, Jose-Maria; Llera, Jose-Manuel
Synthesis, 1996 , # 1 p. 48 - 52