2-溴-2-甲基丙酸乙酯合成路线 （共 239 条）
参考文献
Werner; Bial
Chemische Berichte, 1895 , vol. 28, p. 1374
反应条件
1: 2-amino-3-hydroxy-5-bromopyridine With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.5 h;
2: ethyl 2-bromo-2-methyl propionate in N,N-dimethyl-formamide
T=20 - 80°C; 3.33333 h;
参考文献
TANABE SEIYAKU CO., LTD.
Patent: WO2007/89034 A1, 2007 ;
Location in patent: Page/Page column 77 ;
WO 2007/089034 A1
反应条件
potassium tert-butylate in tert-butyl alcohol
5 h; Heating;
参考文献
Cozzi; Branzoli; Carganico; Chiari; Lovisolo; Severino
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 3 p. 205 - 218
反应条件
1-methyl-piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene
T=180°C; P=7757.22 Torr; 4 h; microwave irradiation;
参考文献
Kamila, Sukanta; Koh, Benjamin; Khan, Omair; Zhang, Hongming; Biehl, Edward R.
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1641 - 1646
反应条件
caesium carbonate in acetonitrile
T=65 - 70°C; 14 h;
参考文献
CADILA HEALTHCARE LIMITED; SHRIVASTAVA, Brijesh Kumar
Patent: WO2012/14221 A1, 2012 ;
Location in patent: Page/Page column 15-16 ;
WO 2012/014221 A1
反应条件
sodium azide in acetonitrile
T=80°C; 48 h;
参考文献
Yuan, Ju-Zhen; Wei, Jia-Jia; Ding, Ming-Wu
Synthetic Communications, 2006 , vol. 36, # 19 p. 2921 - 2925
反应条件
1: hydroquinone in N,N-dimethyl-formamide
T=80°C; 2 h;
2: ethyl 2-bromo-2-methyl propionate in N,N-dimethyl-formamide
T=20°C; 3 h;
3: With hydrogenchloride; water
参考文献
Pierre Fabre Medicament
Patent: US2008/167313 A1, 2008 ;
Location in patent: Page/Page column 15-16 ;
反应条件
potassium carbonate in acetonitrile
20 h; Heating;
参考文献
Oelschlaeger; Rothley; Hellwich; Schmidt
Archiv der Pharmazie, 1989 , vol. 322, # 6 p. 337 - 342
反应条件
1: potassium carbonate
2: hydrogen / palladium 10 on activated carbon / 20 °C
View Scheme
参考文献
Masson, Christophe; Caumont-Bertrand, Karine
Patent: US2011/195993 A1, 2011 ;
US 20110195993 A1
反应条件
(i) Zn, MeMgI, (ii) P2O5, (iii) aq. NaOH; Multistep reaction;
参考文献
Bigley,D.B.; Thurman,J.C.
Journal of the Chemical Society, 1965 , p. 6202 - 6205
