4-氨基-5-氰基-6-氯嘧啶合成路线 （共 4 条）
反应条件
ammonia in 1,4-dioxane; methanol T=0°C; 0.833333 h;
参考文献
ALMIRALL, S.A.; ERRA SOLA, Montserrat; CARRASCAL RIERA, Marta; TALTAVULL MOLL, Joan; CATURLA JAVALOYES, Juan Francisco; BERNAL ANCHUELA, Francisco Javier; PAGES SANTACANA, Lluis Miquel; MIR CEPEDA, Marta; CASALS COLL, Gaspar; HERNANDEZ OLASAGARRE, Maria Begoña
Patent: WO2014/60432 A1, 2014 ;
Location in patent: Page/Page column 159 ;
反应条件
1: thionyl chloride / chloroform / 2 h / 20 °C 2: ammonia / tetrahydrofuran / 0.83 h View Scheme
参考文献
US2011/152296 A1, ;
US2011/245257 A1, ;
WO2012/68343 A1, ;
WO 2012/068343 A1
反应条件
1: hydroxylamine hydrochloride; sodium acetate / ethanol / 2 h / 20 °C 2: thionyl chloride / chloroform / 2 h / 20 °C 3: ammonia / tetrahydrofuran / 0.83 h View Scheme
参考文献
US2011/152296 A1, ;
US2011/245257 A1, ;
WO2012/68343 A1, ;
WO 2012/068343 A1
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Clark,J. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1976 , p. 1004 - 1007
