3,4-二甲氧基-N-甲基-苯甲酰胺合成路线 （共 10 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Lasslo,A. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1960 , vol. 2, p. 617 - 631
反应条件
water; trifluoroacetic acid in acetonitrile
T=80°C; 2 h; Sealed tube;
参考文献
Lee, Sang-Hak; Mu, Yu; Kim, Gun-Woo; Kim, Jin-Seok; Park, Seok-Hwi; Jin, Tian; Lee, Kee-Young; Ham, Won-Hun
Heterocycles, 2013 , vol. 87, # 8 p. 1749 - 1764
参考文献
Salfetnikova; Vasil'ev; Rudenko
Russian Journal of Organic Chemistry, 1998 , vol. 34, # 6 p. 838 - 844
反应条件
triethylamine in dichloromethane
T=0°C;
参考文献
Kong, Wangqing; Casimiro, Maria; Fuentes, Noelia; Merino, Estibaliz; Nevado, Cristina
Angewandte Chemie - International Edition, 2013 , vol. 52, # 49 p. 13086 - 13090
Angew. Chem., 2013 , vol. 125, # 49 p. 13324 - 13328,5
反应条件
1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 25 °C
1.2: 8 h / 80 °C
2.1: trifluoroacetic acid; water / acetonitrile / 2 h / 80 °C / |Sealed tube
View Scheme
参考文献
Lee, Sang-Hak; Mu, Yu; Kim, Gun-Woo; Kim, Jin-Seok; Park, Seok-Hwi; Jin, Tian; Lee, Kee-Young; Ham, Won-Hun
Heterocycles, 2013 , vol. 87, # 8 p. 1749 - 1764
反应条件
potassium tert-butylate; ammonia; acetone
4 h; Irradiation;
参考文献
Beugelmans, Rene; Ginsburg, Helene; Bois-Choussy, Michele
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1149 - 1152
反应条件
potassium tert-butylate; ammonia
4 h; Irradiation;
参考文献
Beugelmans, Rene; Ginsburg, Helene; Bois-Choussy, Michele
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1149 - 1152
反应条件
2,4,6-trichloro-1,3,5-triazine
参考文献
Beugelmans, Rene; Ginsburg, Helene; Bois-Choussy, Michele
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1149 - 1152
参考文献
Narasimhan, Balasubramanian; Ohlan, Sucheta; Ohlan, Ruchita; Judge, Vikramjeet; Narang, Rakesh
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 2 p. 689 - 700
反应条件
1.1: {RuCl2(1-methyl-4-(1-methylethyl)benzene)}2; silver hexafluoroantimonate; silver(l) oxide / tetrahydrofuran / 16 h / 110 °C / |Inert atmosphere
2.1: trifluoroacetic anhydride / 2 h / 100 °C
2.2: 2 h / 100 °C
View Scheme
参考文献
Chinnagolla, Ravi Kiran; Jeganmohan, Masilamani
Organic Letters, 2012 , vol. 14, # 20 p. 5246 - 5249,4
