2-(4-甲基羰基氧基苯基)-1-乙醇合成路线 （共 16 条）
反应条件
1: 1.) Ag2CO3, Drierite, 2.) I2 / 1.) Et2O, RT, 10 min, 2.) Et2O, RT, 14 h 2: 97.7 percent / NaOMe / methanol / 1 h / Ambient temperature View Scheme
参考文献
Shi, Tianyao; Chen, Hui; Jing, Linlin; Liu, Xueying; Sun, Xiaoli; Jiang, Ru
Synthetic Communications, 2011 , vol. 41, # 17 p. 2594 - 2600
反应条件
potassium hydroxide; acetic anhydride in tetrahydrofuran; diethyl ether; water
参考文献
AstraZeneca AB
Patent: US6288096 B1, 2001 ;
反应条件
sodium hydroxide in water
T=0 - 10°C; pH=7 - 8; 1.66667 h; Large scale reaction;
参考文献
Shi, Tianyao; Chen, Hui; Jing, Linlin; Liu, Xueying; Sun, Xiaoli; Jiang, Ru
Synthetic Communications, 2011 , vol. 41, # 17 p. 2594 - 2600
反应条件
cesium fluoride in acetonitrile
T=80°C; 0.5 h;
参考文献
Miyazawa, Toshifumi; Yamamoto, Masato; Danjo, Hiroshi
Monatshefte fur Chemie, 2013 , vol. 144, # 9 p. 1351 - 1354
反应条件
(Cp2TiCl)2; water in tetrahydrofuran; benzene
3 h; Inert atmosphere;
参考文献
Paradas, Miguel; Campana, Araceli G.; Jimenez, Tania; Robles, Rafael; Oltra, J. Enrique; Bunuel, Elena; Justicia, Jose; Cardenas, Diego J.; Cuerva, Juan M.
Journal of the American Chemical Society, 2010 , vol. 132, # 36 p. 12748 - 12756
反应条件
RbF in acetonitrile
T=80°C; 0.5 h; Reagent/catalyst;
参考文献
Miyazawa, Toshifumi; Yamamoto, Masato; Danjo, Hiroshi
Monatshefte fur Chemie, 2013 , vol. 144, # 9 p. 1351 - 1354
反应条件
sodium hydroxide in tetrahydrofuran; water
0.5 h; Ambient temperature;
参考文献
Paradisi, Mario Paglialunga; Zecchini, Giampiero Pagani; Torrini, Ines
Tetrahedron Letters, 1986 , vol. 27, # 41 p. 5029 - 5032
反应条件
RbF in acetonitrile
T=80°C; 0.583333 h; Reagent/catalyst;
参考文献
Miyazawa, Toshifumi; Yamamoto, Masato; Danjo, Hiroshi
Monatshefte fur Chemie, 2013 , vol. 144, # 9 p. 1351 - 1354
反应条件
cesium fluoride in acetonitrile
T=80°C; 0.5 h;
参考文献
Miyazawa, Toshifumi; Yamamoto, Masato; Danjo, Hiroshi
Monatshefte fur Chemie, 2013 , vol. 144, # 9 p. 1351 - 1354
反应条件
cesium fluoride in acetonitrile
T=80°C; 24 h; Reagent/catalyst;
参考文献
Miyazawa, Toshifumi; Yamamoto, Masato; Danjo, Hiroshi
Monatshefte fur Chemie, 2013 , vol. 144, # 9 p. 1351 - 1354
