2-(4-甲基羰基氧基苯基)-1-乙醇合成路线 （共 16 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran
1 h; Ambient temperature;
参考文献
Paradisi, Mario Paglialunga; Zecchini, Giampiero Pagani; Torrini, Ines
Tetrahedron Letters, 1986 , vol. 27, # 41 p. 5029 - 5032
反应条件
triethylamine in tetrahydrofuran
T=60°C; 0.666667 h;
参考文献
Miyazawa, Toshifumi; Yamamoto, Masato; Maeda, Yuki
Synthetic Communications, 2009 , vol. 39, # 6 p. 1092 - 1099
反应条件
1: 93 percent / BBr3 / CH2Cl2 / 0.5 h / -78 °C
2: 95 percent / concd aq. HCl / 0.5 h / Heating
3: 90 percent / NaBH4 / H2O / 8 h / Ambient temperature
4: 73 percent / 1N aq. NaOH / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Kuwajima, Hiroshi; Takai, Yoshitaka; Takaishi, Kiyokazu; Inoue, Kenichiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 4 p. 581 - 586
反应条件
1: 95 percent / concd aq. HCl / 0.5 h / Heating
2: 90 percent / NaBH4 / H2O / 8 h / Ambient temperature
3: 73 percent / 1N aq. NaOH / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Kuwajima, Hiroshi; Takai, Yoshitaka; Takaishi, Kiyokazu; Inoue, Kenichiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 4 p. 581 - 586
反应条件
1: 90 percent / NaBH4 / H2O / 8 h / Ambient temperature
2: 73 percent / 1N aq. NaOH / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Kuwajima, Hiroshi; Takai, Yoshitaka; Takaishi, Kiyokazu; Inoue, Kenichiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 4 p. 581 - 586
反应条件
1: 1.) Mg / 1.) THF, 20 deg C, 30 min, 2.) THF, from 10 deg C to 25 deg C, 1.5 h
2: 93 percent / BBr3 / CH2Cl2 / 0.5 h / -78 °C
3: 95 percent / concd aq. HCl / 0.5 h / Heating
4: 90 percent / NaBH4 / H2O / 8 h / Ambient temperature
5: 73 percent / 1N aq. NaOH / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Kuwajima, Hiroshi; Takai, Yoshitaka; Takaishi, Kiyokazu; Inoue, Kenichiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 4 p. 581 - 586
