3-乙酰基-1-甲基-2-吡咯烷酮合成路线 （共 3 条）
反应条件
1: n-butyllithium With N-ethyl-N,N-diisopropylamine in tetrahydrofuran; hexane
0.333333 h; Inert atmosphere;
2: 1-methyl-pyrrolidin-2-one T=-78°C; 1 h;
参考文献
Vifor (International) AG; Bark, Thomas; Buhr, Wilm; Burckhardt, Susanna; Burgert, Michael; Canclini, Camillo; Dürrenberger, Franz; Funk, Felix; Geisser, Peter; Kalogerakis, Aris; Mayer, Simona; Philipp, Erik; Reim, Stefan; Sieber, Diana; Schmitt, Jörg; Schwarz, Katrin
Patent: US2013/109662 A1, 2013 ;
Location in patent: Paragraph 0352; 0353; 0354; 0355 ;
反应条件
mercury dichloride
T=18 - 20°C; 3 h;
参考文献
Kramarova, E. P.; Anisomova, N. A.; Baukov, Yu. I.
J. Gen. Chem. USSR (Engl. Transl.), 1991 , vol. 61, # 6.2 p. 1406 - 1413,1284 - 1290
反应条件
1: 1) sodium bis(trimethylsilyl)amide / 1) ether, -60 deg C, 30 min, 2) -60 deg C to r.t.
2: 45 percent / HgCl2 / 3 h / 18 - 20 °C
View Scheme
参考文献
Kramarova, E. P.; Anisomova, N. A.; Baukov, Yu. I.
J. Gen. Chem. USSR (Engl. Transl.), 1991 , vol. 61, # 6.2 p. 1406 - 1413,1284 - 1290
