外消旋alpha-羟基布洛芬合成路线 （共 19 条）
反应条件
sulfuric acid; acetic acid; palladium monocarbide in water; hydrogen
参考文献
Ube Industries, Ltd.
Patent: US4922010 A1, 1990 ;
反应条件
sulfuric acid in water; acetic acid
参考文献
SANOFI and Industria Chimica Prodotti FRANCIS S.p.A.
Patent: US4713485 A1, 1987 ;
反应条件
hydrogen iodide in water T=90°C; 18 h;
参考文献
Aramini, Andrea; Sablone, Manolo R.; Bianchini, Gianluca; Amore, Alessia; Fani, Michela; Perrone, Plinio; Dolce, Alberto; Allegretti, Marcello
Tetrahedron, 2009 , vol. 65, # 10 p. 2015 - 2021
参考文献
SANOFI and Industria Chimica Prodotti FRANCIS S.p.A.
Patent: US4713485 A1, 1987 ;
反应条件
ethanol; potassium hydroxide
T=20°C; 4 h;
参考文献
Liang, Yu-Feng; Jiao, Ning
Angewandte Chemie - International Edition, 2014 , vol. 53, # 2 p. 548 - 552
Angew. Chem., 2014 , vol. 53, # 2 p. 558 - 562,5
反应条件
hydrogenchloride; sodium hydroxide; sodium hydrogencarbonate; aluminium trichloride in ethanol; dichloromethane; toluene
参考文献
Ube Industries, Ltd.
Patent: US4922010 A1, 1990 ;
反应条件
tetra-(n-butyl)ammonium iodide; magnesium in N,N-dimethyl-formamide
T=5°C; Electrolysisatmospheric pressure;
参考文献
Damodar; Raju, R. Ramesh; Reddy, S. Jayarama
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 12 p. 2655 - 2658
反应条件
sodium hydroxide in anhydrous xylene; water
参考文献
Sanofi
Patent: US4675419 A1, 1987 ;
反应条件
hydrogenchloride; water in 1,4-dioxane
Reflux;
参考文献
Aramini, Andrea; Sablone, Manolo R.; Bianchini, Gianluca; Amore, Alessia; Fani, Michela; Perrone, Plinio; Dolce, Alberto; Allegretti, Marcello
Tetrahedron, 2009 , vol. 65, # 10 p. 2015 - 2021
反应条件
potassium tert-butylate in hexane
0.5 h; Ambient temperature;
参考文献
Garcia; Del Campo; Llama; Sanchez-Montero; Sinisterra
Tetrahedron, 1993 , vol. 49, # 37 p. 8433 - 8440
