3,4-亚甲二氧基苯乙醇合成路线 （共 17 条）
反应条件
1: 83 percent / Ph3P, Br2 / CH2Cl2 / 0.5 h / 20 °C 2: 80 percent / NaH / dimethylformamide; tetrahydrofuran / 17 h / 40 °C View Scheme
参考文献
De Oliveira, Eduardo R.; Dumas, Francoise; D'Angelo, Jean
Tetrahedron Letters, 1997 , vol. 38, # 21 p. 3723 - 3726
反应条件
1.1: tin(IV) chloride / 0 - 25 °C / Inert atmosphere 2.1: acetyl chloride / 4 h / Inert atmosphere; Reflux 2.2: 1 h / 90 - 100 °C / Inert atmosphere 3.1: titanium tetraethoxide / dichloromethane / 4 h / Reflux; Inert atmosphere 4.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 4.2: -78 - 20 °C / Inert atmosphere 5.1: trifluoroacetic acid / methanol / 3 h / 0 °C / Inert atmosphere 6.1: trifluoroacetic acid / toluene / 0.5 h / 140 °C / Microwave irradiation 6.2: pH 8 View Scheme
参考文献
Mastranzo, Virginia M.; Olivares Romero, Jose Luis; Yuste, Francisco; Ortiz, Benjamin; Sanchez-Obregon, Ruben; Garcia Ruano, Jose L.
Tetrahedron, 2012 , vol. 68, # 4 p. 1266 - 1271
反应条件
silica gel; pyridinium chlorochromate in dichloromethane
参考文献
Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Podloucka, Anna; Taylor, David A.
Australian Journal of Chemistry, 2003 , vol. 56, # 9 p. 875 - 886
反应条件
acetic anhydride in pyridine
参考文献
Texas Biotechnology Corporation
Patent: US5962490 A1, 1999 ;
US 5962490 A
Title/Abstract Full Text Show Details
Chan, Ming Fai; Kogan, Timothy; Verner, Erik Joel; Kois, Adam; Balaji, Vitukudi Narayanaiyengar
Patent: US2002/95041 A1, 2002 ;
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=23°C; 0.5 h;
参考文献
Boehm; Gleason; Pendrak; Sarau; Schmidt; Foley; Kingsbury
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3333 - 3340
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 3 h; Inert atmosphere;
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
参考文献
McNeilab, Inc.
Patent: EP256888 B1, 1991 ;
