(S)-2-氨基-2-苯乙酰胺盐酸盐合成路线 (共 3 条)
反应条件
chiral stationary phase including isopropyl-functionalized CF6 in methanol; acetic acid; triethylamine; acetonitrile T=20°C; Purification / work up;
参考文献
WO2010/148191 A2, ;
Page/Page column 45-49; 60 ;
反应条件
hydrogenchloride in 1,4-dioxane
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 25 p. 5471 - 5482
反应条件
1.1: HOBt; EDC / dimethylformamide / 0.25 h / 0 °C 1.2: ammonium hydroxide / dimethylformamide 2.1: 4 N HCl / dioxane View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 25 p. 5471 - 5482