2-(4-氯-2-硝基苯基)氨基苯甲酸合成路线 （共 17 条）
反应条件
1: 64 percent / Na2S2O4 / aq. NH3 / 80 °C 2: 79 percent / xylene / 96 h / Heating View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
hydrogen; platinum on sulfide coal in ethyl acetate P=1500.15 Torr; 5 h;
参考文献
AKZO NOBEL N.V.
Patent: WO2003/84963 A1, 2003 ;
Location in patent: Page/Page column 18; 65 ;
WO 03/084963 A1
反应条件
copper; potassium carbonate in pentan-1-ol
T=120 - 140°C; 2.5 h;
参考文献
AKZO NOBEL N.V.
Patent: WO2003/84963 A1, 2003 ;
Location in patent: Page/Page column 18; 64-65 ;
WO 03/084963 A1
反应条件
1: With copper; potassium carbonate in 3-methyl-1-butanol
4 h; Reflux;
2: With hydrogenchloride in water
参考文献
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Patent: EP2199295 A1, 2010 ;
Location in patent: Page/Page column 35 ;
反应条件
hydrogenchloride; potassium carbonate in N-methyl-acetamide; methanol; dichloromethane
参考文献
Auspex Pharmaceuticals, Inc.
Patent: US2010/166887 A1, 2010 ;
US 20100166887 A1
反应条件
copper; potassium carbonate in various solvent(s)
Ullmann reaction; 4 h; Heating;
参考文献
Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A.
Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 565 - 576
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=140°C;
参考文献
Ruger; Rohnert; Lohmann
Pharmazie, 1990 , vol. 45, # 8 p. 555 - 559
反应条件
copper(l) iodide; potassium carbonate in N,N-dimethyl-formamide
T=120°C; Ullmann Condensation; 4 h;
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: hydrogenchloride / water / 2 h / |Reflux
2: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: nitric acid; sulfuric acid / 2 h / 70 °C
2: potassium permanganate; water / 8 h / |Reflux
3: palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C
4: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C
5: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
