2-(4-氯-2-硝基苯基)氨基苯甲酸合成路线 （共 17 条）
反应条件
1: potassium permanganate; water / 8 h / |Reflux
2: palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C
3: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C
4: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C
2: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C
3: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C
2: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: dichloromethane / 1 h / 20 °C
2: nitric acid; acetic acid / 0.5 h / 0 °C
3: hydrogenchloride / water / 2 h / |Reflux
4: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: nitric acid; acetic acid / 0.5 h / 0 °C
2: hydrogenchloride / water / 2 h / |Reflux
3: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: 90 percent / DVP-Fe, conc. HCl / aq. ethanol; H2O / Heating
2: conc. H3PO4 / xylene / 140 °C
3: 90 percent / xylene / Heating
4: dimethylformamide / 8 h / Ambient temperature
View Scheme
参考文献
Ruger; Rohnert; Lohmann
Pharmazie, 1990 , vol. 45, # 8 p. 555 - 559
反应条件
1: 64 percent / Na2S2O4 / aq. NH3 / 80 °C
2: 79 percent / xylene / 96 h / Heating
3: 69 percent / TiCl4 / dioxane / 24 h / Heating
View Scheme
参考文献
Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A.
Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 565 - 576
