（2R，3S，5R）-5-（4-氨基-7H-吡咯[2,3-D]嘧啶-7-基-2 -（羟甲基）四氢呋喃-3-醇合成路线 （共 28 条）
反应条件
hydrogen; potassium carbonate; palladium on activated charcoal in propan-1-ol P=1520 Torr; 2 h;
参考文献
Kazimierczuk, Zygmunt; Cottam, Howard B.; Revankar, Ganapathi R.; Robins, Roland K.
Journal of the American Chemical Society, 1984 , vol. 106, # 21 p. 6379 - 6382
反应条件
ammonia in methanol T=120°C; 12 h;
参考文献
Kazimierczuk, Zygmunt; Cottam, Howard B.; Revankar, Ganapathi R.; Robins, Roland K.
Journal of the American Chemical Society, 1984 , vol. 106, # 21 p. 6379 - 6382
反应条件
hydrogen; potassium carbonate; palladium on activated charcoal in propan-1-ol; water P=1520 Torr; 8 h;
参考文献
Cottam, Howard B.; Kazimierczuk, Zygmunt; Geary, Stewart; McKernan, Patricia A.; Revankar, Ganapathi R.; Robins, Roland K.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1461 - 1467
反应条件
1: 1.) NaH / 1.) acetonitrile, r.t., 30 min; 2.) 50 deg C, 2 h 2: 61 percent / ammonia / methanol / 12 h / 100 °C 3: 90 percent / K2CO3, hydrogen / 10percent Pd/C / aq. propan-1-ol / 2 h / 1520 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 21 p. 6379 - 6382
反应条件
Raney nickel (W-4) in isopropyl alcohol 5 h; Heating;
参考文献
Kazimierczuk, Zygmunt; Cottam, Howard B.; Revankar, Ganapathi R.; Robins, Roland K.
Journal of the American Chemical Society, 1984 , vol. 106, # 21 p. 6379 - 6382
反应条件
1: 1.) NaH / 1.) acetonitrile, r.t., 30 min; 2.) 50 deg C, 2 h 2: 61 percent / ammonia / methanol / 12 h / 100 °C 3: 90 percent / K2CO3, hydrogen / 10percent Pd/C / aq. propan-1-ol / 2 h / 1520 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 21 p. 6379 - 6382
反应条件
1: 61 percent / ammonia / methanol / 12 h / 100 °C 2: 90 percent / K2CO3, hydrogen / 10percent Pd/C / aq. propan-1-ol / 2 h / 1520 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 21 p. 6379 - 6382
反应条件
1: 72 percent / ammonia / methanol / 12 h / 100 °C 2: 70 percent / Raney nickel (W-4) / propan-2-ol / 5 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 21 p. 6379 - 6382
反应条件
1: 8 percent / phosphorus oxychloride, N,N-dimethylaniline / 2.5 h / Heating 2: 1.) NaH / 1.) acetonitrile, r.t., 30 min; 2.) 50 deg C, 2 h 3: 61 percent / ammonia / methanol / 12 h / 100 °C 4: 90 percent / K2CO3, hydrogen / 10percent Pd/C / aq. propan-1-ol / 2 h / 1520 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 21 p. 6379 - 6382
反应条件
1: 1.) NaH / 1.) acetonitrile, r.t., 30 min; 2.) 50 deg C, 2 h 2: 72 percent / ammonia / methanol / 12 h / 100 °C 3: 70 percent / Raney nickel (W-4) / propan-2-ol / 5 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 21 p. 6379 - 6382
