（2R，3S，5R）-5-（4-氨基-7H-吡咯[2,3-D]嘧啶-7-基-2 -（羟甲基）四氢呋喃-3-醇合成路线 （共 28 条）
反应条件
nickel in ethanol; water 2.5 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1461 - 1467
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=120°C; Reduction; 56 h;
参考文献
Nucleosides and Nucleotides, , vol. 18, # 11-12 p. 2697 - 2709
反应条件
1: 1.) NaH / 1.) CH3CN, RT, 30 min, 2.) CH3CN, 30 min 2: 82 percent / NH3 / methanol / 16 h / 120 °C 3: 66 percent / Raney nickel / H2O; ethanol / 2.5 h / Heating 4: 90 percent / H2, K2CO3 / 10percent Pd/C / H2O; propan-1-ol / 8 h / 1520 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1461 - 1467
反应条件
1: 82 percent / NH3 / methanol / 16 h / 120 °C 2: 66 percent / Raney nickel / H2O; ethanol / 2.5 h / Heating 3: 90 percent / H2, K2CO3 / 10percent Pd/C / H2O; propan-1-ol / 8 h / 1520 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1461 - 1467
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran Heating;
参考文献
Journal of the American Chemical Society, , vol. 105, # 12 p. 4059 - 4065
反应条件
1: 1.) NaH / 1.) acetonitrile, r.t., 30 min; 2.) 50 deg C, 2 h 2: 85 percent / ammonia / methanol / 12 h / 120 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 21 p. 6379 - 6382
反应条件
1: 1.) HCl (gas), 2.) NaOEt / 1.) EtOH, 0-5 deg C, 24 h, 2.) EtOH, reflux, 2.5 h 2: 82 percent / NH4OH, NaOH, Raney Ni / H2O / 2 h / Heating 3: 47 percent / POCl3, N,N-dimethylaniline / 3 h / Heating 4: 1.) NaH / 1.) CH3CN, 30 min, 2.) CH3CN, RT, overnight 5: 79 percent / NH3 / methanol / 16 h / 120 °C 6: 90 percent / H2, K2CO3 / 10percent Pd/C / H2O; propan-1-ol / 8 h / 1520 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1461 - 1467
反应条件
1: 47 percent / POCl3, N,N-dimethylaniline / 3 h / Heating 2: 1.) NaH / 1.) CH3CN, 30 min, 2.) CH3CN, RT, overnight 3: 79 percent / NH3 / methanol / 16 h / 120 °C 4: 90 percent / H2, K2CO3 / 10percent Pd/C / H2O; propan-1-ol / 8 h / 1520 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1461 - 1467
反应条件
1: 1.) NaH / 1.) CH3CN, 30 min, 2.) CH3CN, RT, overnight 2: 79 percent / NH3 / methanol / 16 h / 120 °C 3: 90 percent / H2, K2CO3 / 10percent Pd/C / H2O; propan-1-ol / 8 h / 1520 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1461 - 1467
反应条件
1: 82 percent / NH4OH, NaOH, Raney Ni / H2O / 2 h / Heating 2: 47 percent / POCl3, N,N-dimethylaniline / 3 h / Heating 3: 1.) NaH / 1.) CH3CN, 30 min, 2.) CH3CN, RT, overnight 4: 79 percent / NH3 / methanol / 16 h / 120 °C 5: 90 percent / H2, K2CO3 / 10percent Pd/C / H2O; propan-1-ol / 8 h / 1520 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1461 - 1467
